Phosphonic acid, (chloromethyl)-, diethyl ester

Phosphonic acid, (chloromethyl)-, diethyl ester structural formula

CAS Number3167-63-3
Molecular FormulaC5H12ClO3P
Molecular Weight186.571
  • Phosphonic acid, (chloromethyl)-, diethyl ester
  • Diethyl (chloromethyl)phosphonate
  • Phosphonic acid, P-(chloromethyl)-, diethyl ester
  • 3167-63-3
  • Chloromethylphosphonic acid diethyl ester
  • Diethyl chloromethanephosphonate
  • EINECS 221-632-5
  • NSC 67753


Separation of Phosphonic acid, (chloromethyl)-, diethyl ester on Newcrom R1 HPLC column

February 16, 2018
Separation of Phosphonic acid, (chloromethyl)-, diethyl ester on Newcrom C18 HPLC column

Phosphonic acid, (chloromethyl)-, diethyl ester can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Phosphonic acid, (chloromethyl)-, diethyl ester
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: or by phone: 847-229-2629.