Patulin

Patulin structural formula

CAS Number149-29-1
Molecular FormulaC7H6O4
Molecular Weight154.121
InChI KeyZRWPUFFVAOMMNM-UHFFFAOYSA-N
LogP-0.755
Synonyms
  • Patulin
  • 4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one
  • 4H-Furo[3,2-c]pyran-2(6H)-one, 4-hydroxy-
  • 149-29-1
  • 4-Hydroxy-4H-furo[3,2c]pyran-2(6H)-one
  • 4H-Furo[3,2-c]pyran-2(6H)-one, 4-hydroxy-
  • 5-18-03-00005
  • 4,6-dihidro-4-hidroxi-2H-furo[3,2-c]piran-2-ona
  • 4,6-Dihydro-4-hydroxy-2H-furo[3,2-c]pyran-2-on
  • 4,6-dihydro-4-hydroxy-2H-furo[3,2-c]pyran-2-one
  • 4,6-dihydro-4-hydroxy-2H-furo[3,2-c]pyranne-2-one
  • 4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one
  • Acetic acid, (2,4-dihydroxy-2H-pyran-3(6H)-ylidene)-, 3,4-lactone
  • Clairformin
  • Clavacin
  • Clavatin
  • Claviformin
  • DL-Patulin
  • Expansin
  • Expansine
  • Mycoin C
  • NSC 32951
  • NSC 8120
  • Patuline
  • Penicidin
  • Terinin
  • BRN 0149675
  • 2,4-Dihydroxy-2H-pyran-delta-3(6H),alpha-acetic acid-3,4-lactone
  • (2,4-Dihydroxy-2H-pyran-3(6H)-ylidene)acetic acid, 3,4-lactone
  • EINECS 205-735-2
  • 4H-Furo(3,3-c)pyran-2(6H)-one, 4-hydroxy-
  • 4-Hydroxy-4H-furo(3,2-c)pyran-2(6H)-one
  • Leucopin
  • Mycosin
  • 2H-Pyran-delta(sup 3(6H),alpha)-acetic acid, 2,4-dihydroxy-, 3,4-lactone
  • Tercinin
  • UNII-95X2BV4W8R
  • (2,4-dihydroxy-2H-pyran-3(6H)-ylidene)acetic acid-3,4-lactone
  • 4,6-dihydro-4-hydroxy-2H-furo(3,2-c)pyran-2-one
  • PAT
  • claviform
  • mycoin C3
  • mycoine C3

Applications:

HPLC Method For Analysis Of  Patulin on Newcrom R1 Column

August 19, 2021

Separation type: Liquid Chromatography Reverse Phase.


HPLC.cloud
View on hplc.cloud

High Performance Liquid Chromatography (HPLC) Method for Analysis of Patulin.

Patulin is a toxic chemical contaminant produced by several species of mold, especially within Byssochlamys Aspergillus and Penicillium. It is the most common mycotoxin found in apples and apple-derived products such as juice, cider, compotes and other food intended for young children. Patulin can be retained in HPLC on Newcrom R1 reverse-phase column with the simple isocratic mobile phase consisting of acetonitrile (MeCN, ACN), water and Phosphoric Acid (H3PO4) buffer. The analysis method can be UV detected at 275 nm.

Condition
Column Newcrom R1, 3.2×100 mm, 5 µm, 100A
Mobile Phase MeCN – 10%
Buffer H3PO4 – 0.2%
Flow Rate 0.5 ml/min
UV Detection 275 nm
LOD 0.002 ppm

Description
Class of Compounds Hydrophilic
Analyzing Compounds Patulin

 

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Patulin
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Patulin on Newcrom R1 HPLC column

February 16, 2018
Separation of Patulin on Newcrom C18 HPLC column

Patulin can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Patulin
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.