Nicomorphine [INN:BAN:DCF]

Nicomorphine [INN:BAN:DCF] structural formula

CAS Number639-48-5
Molecular FormulaC29H25N3O5
Molecular Weight495.536
InChI KeyHNDXBGYRMHRUFN-CIVUWBIHSA-N
LogP2.70
Synonyms
  • Nicomorphine [INN:BAN:DCF]
  • (5alpha,6alpha)-17-Methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diyl dipyridine-3-carboxylate
  • 3-Pyridinecarboxylic acid, (5alpha,6alpha)-7,8-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diyl ester
  • 639-48-5
  • EINECS 211-357-9
  • Morphine dinicotinate
  • 3,6-Dinicotinoylmorphine
  • Di-O-nicotinoylmorphine
  • Morphine diester with nicotinic acid
  • Nicotinic acid diester with morphine
  • Di-nicotinsaeureester von morphin
  • 4,5-Eposy-N-methyl-7-morphinen-3,6alpha-diyl bis(nicotinat)
  • 4,5alpha-Epoxy-17-methyl-7-methyl-7-morphinen-3,6-diyldinicotinat
  • Nicomorfina
  • Nicomorphinum
  • UNII-Y95FRL95FW

Applications:

Separation of Nicomorphine [INN:BAN:DCF] on Newcrom R1 HPLC column

February 16, 2018
Separation of Nicomorphine [INN:BAN:DCF] on Newcrom C18 HPLC column

Nicomorphine [INN:BAN:DCF] can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Nicomorphine [INN:BAN:DCF]
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.