Nalmefene hydrochloride dihydrate

Nalmefene hydrochloride dihydrate structural formula

CAS Number1228646-70-5
Molecular FormulaC21H30ClNO5
Molecular Weight411.921
InChI KeyXOBQQQVDLSMXCE-JVRGSUDVSA-N
LogP2.20
Synonyms
  • Nalmefene hydrochloride dihydrate
  • (5alpha)-17-(Cyclopropylmethyl)-6-methylidene-4,5-epoxymorphinan-3,14-diol--hydrogen chloride--water (1/1/2)
  • Morphinan-3,14-diol, 17-(cyclopropylmethyl)-4,5-epoxy-6-methylene-, (5alpha)-, hydrochloride, hydrate (1:1:2)
  • 1228646-70-5
  • UNII-52Z0G7QVJX
  • Morphinan-3,14-diol, 17-(cyclopropylmethyl)-4,5-epoxy-6-methylene-, hydrochloride, hydrate (1:1:2), (5alpha)-

Applications:

Separation of Nalmefene hydrochloride dihydrate on Newcrom R1 HPLC column

May 16, 2018
Separation of Nalmefene hydrochloride dihydrate on Newcrom R1 HPLC column

Nalmefene hydrochloride dihydrate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Nalmefene hydrochloride dihydrate
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.