Methylprednisolone acetate

Methylprednisolone acetate structural formula

CAS Number53-36-1
Molecular FormulaC24H32O6
Molecular Weight416.515
InChI KeyPLBHSZGDDKCEHR-LFYFAGGJSA-N
LogP2.65
Synonyms
  • Methylprednisolone acetate
  • (6alpha,11beta)-11,17-Dihydroxy-6-methyl-3,20-dioxopregna-1,4-dien-21-yl acetate
  • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-6-methyl-, (6alpha,11beta)-
  • 53-36-1
  • Depo-Medrate
  • Depo-Medrone
  • EINECS 200-171-3
  • Medrol acetate
  • Medrol Enpak
  • NSC 48985
  • M-Predrol
  • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-6-methyl-, (6-alpha,11-beta)-
  • Urbason crystal suspension
  • Demethyl
  • Depo-Medrin
  • Depometicort
  • Lemod Depo
  • Unidrol
  • Solsolona
  • Ubrason
  • UNII-43502P7F0P
  • Methyl prednisolone acetate
  • 11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-acetate
  • 6alpha-Methylprednisolone 21-acetate
  • 6alpha-Methylprednisolone acetate
  • Depo-Methylprednisolone acetate
  • Depo-medrol
  • M-Predrol
  • Methylprednisolone 21-acetate

Applications:

Separation of Methylprednisolone acetate on Newcrom R1 HPLC column

February 19, 2018
Separation of Methylprednisolone acetate on Newcrom C18 HPLC column

Methylprednisolone acetate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Methylprednisolone acetate
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.