Methadone hydrochloride

Methadone hydrochloride structural formula

CAS Number1095-90-5
Molecular FormulaC21H28ClNO
Molecular Weight345.911
InChI KeyFJQXCDYVZAHXNS-UHFFFAOYSA-N
LogP3.91
Synonyms
  • Methadone hydrochloride
  • 6-(Dimethylamino)-4,4-diphenylheptan-3-one--hydrogen chloride (1/1)
  • 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, hydrochloride (1:1)
  • 1095-90-5
  • 6-Dimethylamino-4,4-diphenyl-3-heptanone.HCl
  • Althose hydrochloride
  • 6-(Dimethylamino)-4,4-diphenyl-3-heptanone hydrochloride
  • EINECS 214-140-7
  • Mecodin
  • Methadose
  • 4,4-Diphenyl-6-dimethylamino-3-heptanone hydrochloride
  • (+-)-Methadone hydrochloride
  • Algidon
  • Butalgin
  • Depridol
  • Diaminon hydrochloride
  • dl-6-Dimethylamino-4,4-diphenyl-3-heptanone hydrochloride
  • Dolofin hydrochloride
  • Fenadon
  • Fenadone
  • Ketalgin hydrochloride
  • Miadone
  • Moheptan
  • Polamidon
  • Racemic methadone hydrochloride
  • NSC 19600
  • (+-)-Tussal
  • Dolohepton
  • Diskets dispersible
  • Methadose Oral Concentrate
  • Methadose Sugar-Free Oral
  • Dolophine hydrochloride
  • Methadone hydrochloride intensol
  • Westadone
  • Methadone HCl
  • UNII-229809935B
  • Algolysin
  • DL-Methadone hydrochloride
  • Phenadone hydrochloride

Applications:

Separation of Methadone hydrochloride on Newcrom R1 HPLC column

February 16, 2018
Separation of Methadone hydrochloride on Newcrom C18 HPLC column

Methadone hydrochloride can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Methadone hydrochloride
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.