Metformin hydrochloride

Metformin hydrochloride structural formula

CAS Number1115-70-4
Molecular FormulaC4H12ClN5
Molecular Weight165.631
InChI KeyOETHQSJEHLVLGH-UHFFFAOYSA-N
LogP-1.05
Synonyms
  • Metformin hydrochloride
  • N,N-Dimethyltriimidodicarbonic diamide--hydrogen chloride (1/1)
  • Imidodicarbonimidic diamide, N,N-dimethyl-, hydrochloride (1:1)
  • 1115-70-4
  • Diabefagos
  • Diformin
  • N1,N1-Dimethylbiguanide hydrochloride
  • 1,1-Dimethylbiguanide hydrochloride
  • DMGG hydrochloride
  • EINECS 214-230-6
  • Glucophage
  • Haurymellin hydrochloride
  • Metiguanide monohydrochloride
  • NSC 91485
  • Glyformin
  • Apo-Metformin
  • Benofomin
  • Diaberit
  • Diabesin
  • Diabetex
  • Diabetmin
  • Diaformin
  • Diaphage
  • Diformin Retard
  • Fornidd
  • Glibomet
  • Glucofago
  • Glucoform
  • Glucoliz
  • Glucomet
  • Glucomine
  • Gluconil
  • Glucophage 850
  • Glucophage Forte
  • Glucophage Retard
  • Glucophage-Mite
  • Gluformin
  • Glupermin
  • Glyciphage
  • Glycoran
  • Islotin retard
  • Meglucon
  • Mescorit
  • Metforal
  • Metolmin
  • Metomin
  • Novo-Metformin
  • Risidon
  • Siamformet
  • Thiabet
  • Walaphage
  • Denkaform
  • Fortamet
  • Glumetza
  • Glucophage XR
  • UNII-786Z46389E
  • Metformin HCl ER
  • 1,1-Dimethylbiguanide monohydrochloride
  • Dimethylbiguanide hydrochloride
  • Glucophage (TN)
  • Metformin HCl
  • Metformin monohydrochloride
  • Metiguanide monohydrochloride
  • N,N-Dimethylbiguanide hydrochloride
  • N1,N1-Dimethylbiguanide

Applications:

Separation of Metformin hydrochloride on Newcrom R1 HPLC column

May 16, 2018
Separation of Metformin hydrochloride on Newcrom R1 HPLC column

Metformin hydrochloride can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Metformin hydrochloride
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.