Indole

Indole structural formula

CAS Number120-72-9
Molecular FormulaC8H7N
Molecular Weight117.152
InChI KeySIKJAQJRHWYJAI-UHFFFAOYSA-N
LogP2.14
Synonyms
  • Indole
  • 1H-Indole
  • 120-72-9
  • 1-Azaindene
  • 1-Benzazole
  • 2,3-Benzopyrrole
  • Benzo[b]pyrrole
  • NSC 1964
  • 2,3-Benzopyrole
  • Benzopyrrole
  • 1-Benzo(b)pyrrole
  • Caswell No. 498B
  • EINECS 204-420-7
  • EPA Pesticide Chemical Code 025000
  • FEMA No. 2593
  • UNII-8724FJW4M5
  • Indol
  • 1H-indole

Applications:

Separation of Indole on Newcrom R1 HPLC column

February 16, 2018
Separation of Indole on Newcrom C18 HPLC column

Indole is a white solid that smells heavily of feces at room temperature; however, at lower concentrations, the odor is described to be jasmine-like. Indole is common molecule in nature and is a precursor to many other organic molecules. Indole can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications, the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particle columns are available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation of impurities in preparative separation. It also suitable for pharmacokinetics.
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Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Indole
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.