Hydrocortisone 21-phosphate

Hydrocortisone 21-phosphate structural formula

CAS Number3863-59-0
Molecular FormulaC21H31O8P
Molecular Weight442.446
InChI KeyBGSOJVFOEQLVMH-VWUMJDOOSA-N
LogP0.679
Synonyms
  • Hydrocortisone 21-phosphate
  • (11beta)-11,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl dihydrogen phosphate
  • Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, (11beta)-
  • 3863-59-0
  • Corphos
  • EINECS 223-382-2
  • Hydrocortisone 21-(dihydrogen phosphate)
  • Hydrocortisone phosphate
  • Hydrocortisone-21-phosphate
  • 21-Hydrocortisonephosphoric acid
  • NSC 529660
  • UNII-2Y87E22X71
  • Cortisol phosphate

Applications:

Separation of Hydrocortisone 21-phosphate on Newcrom R1 HPLC column

May 16, 2018
Separation of Hydrocortisone 21-phosphate on Newcrom R1 HPLC column

Hydrocortisone 21-phosphate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Hydrocortisone 21-phosphate
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.