Celebrex, also known by its generic name celecoxib, is a nonsteroidal anti-inflammatory drug (NSAID) primarily used to treat pain and inflammation associated with various conditions such as arthritis, menstrual pain, and other acute pain conditions.
Uses
- Arthritis: Effective in managing symptoms of osteoarthritis and rheumatoid arthritis by reducing inflammation, pain, and stiffness.
- Acute Pain: Prescribed for short-term relief of acute pain, such as postoperative pain.
- Menstrual Pain: Used to alleviate the pain associated with primary dysmenorrhea (menstrual cramps).
- Ankylosing Spondylitis: Helps in reducing pain and stiffness associated with ankylosing spondylitis, a type of arthritis affecting the spine.
Mechanism of Action
Celebrex works by selectively inhibiting the enzyme cyclooxygenase-2 (COX-2), which plays a key role in the production of prostaglandins. Prostaglandins are chemicals in the body that promote inflammation, pain, and fever. By blocking COX-2, Celebrex reduces the levels of these chemicals, thereby alleviating pain and inflammation.
Interactions
Celebrex may interact with:
- Anticoagulants (e.g., warfarin) increasing the risk of bleeding.
- Other NSAIDs or corticosteroids increasing the risk of gastrointestinal issues.
- ACE inhibitors or ARBs reducing their antihypertensive effect and potentially worsening kidney function.
Conclusion
Celebrex is an effective medication for managing pain and inflammation in various conditions. However, it should be used with caution due to its potential side effects and interactions. It’s important to follow the prescribed dosage and consult with a healthcare provider regarding any concerns or preexisting conditions that may affect its use.
Celebrex can be retained, and analyzed using a Primesep 200 mixed-mode stationary phase column. The analysis utilizes an gradient method with a simple mobile phase consisting of water, acetonitrile (MeCN), and phosphoric acid as a buffer. Detection is achieved using UV 270 nm
| Column | Primesep 200, 3.2×100 mm, 5 µm, 100A |
| Mobile Phase | MeCN – 40% |
| Buffer | H3PO4 – 0.1%, |
| Flow Rate | 0.5 ml/min |
| Detection | UV, 270 nm |
| Class of Compounds | Drug, Acid, Hydrophilic, Ionizable, Supplements |
| Analyzing Compounds | Celebrex |
Application Column
Primesep 200
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
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