Separation type: Liquid Chromatography Mixed-mode
Dextromethorphan is a cough suppressant that works by affecting the cough reflex in the brain. It is commonly found in the over-the-counter cough and cold medicines. Dextromethorphan can be retained and analyzed on a Primesep 100 mixed-mode stationary phase column using an isocratic analytical method with a simple mobile phase of water, Acetonitrile (MeCN), and a Sulfuric acid (H2SO4) buffer. This analysis method can be detected in the low UV regime at 225 and 280 nm.
Column | Primesep 100, 4.6×150 mm, 5 µm, 100A |
Mobile Phase | MeCN/H2O – 80/20% |
Buffer | H2SO4 – 0.2% |
Flow Rate | 1.0 ml/min |
Detection | UV 225, 280 nm |
Peak Retention Time | 4.81 min |
Class of Compounds | Drug |
Analyzing Compounds | Dextromethorphan |
Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
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