HPLC Chiral Separation of 2-Phenylpropylamine Enantiomers on Cyralis AL Column

HPLC Chiral Method for Analysis of 2-Phenylpropylamine Enantiomers on Cyralis AL Column by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of 2-Phenylpropylamine.

2-Phenylpropylamine is an organic compound with the chemical formula C9H13N. Not much is known about the substance, but it shares properties with amphetamine. It is said to have antihypotensive activity. It is associated with a case of cerebral hemorrhage in Sweden.

You can find detailed UV spectra of 2-Phenylpropylamine and information about its various lambda maxima by visiting the following link.

This application describes a normal-phase chiral HPLC method for the separation of [compound] enantiomers using SIELC’s Cyralis AL chiral column. Cyralis AL is an amylose-based chiral stationary phase (CSP) designed for enantiomeric separations, optical purity testing, chiral impurity analysis, and stereoisomer characterization in pharmaceutical, chemical, agrochemical, and fine chemical applications.

2-Phenylpropylamine can be retained and analyzed using the Cyralis AL stationary phase column. The analysis utilizes an isocratic method with a mobile phase consisting of Hexane, IPA, and 1-butylamine. Detection is performed using UV.

Condition

ColumnCyralis AL, 4.6 x 250 mm, 5 µm, 100 A, normal phase
Mobile PhaseHexane/IPA/1-butylamine
Flow Rate1.0 mL/min
DetectionUV 250 nm
Resolution2.34

Description

Class of CompoundsOrganic Compound
Analyzing Compounds2-Phenylpropylamine

Application Column

Cyralis AL

Column Diameter: 4.6 mm
Column Length: 250 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: normal phase

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Application Analytes:
2-Phenylpropylamine
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.