HPLC Chiral Separation of 2-amino-1,2-diphenylethanol Enantiomers on Cyralis AM Column

HPLC Chiral Method for Analysis of (1S,2R)-(+)-2-Amino-1,2-diphenylethanol Enantiomers on Cyralis AM Column by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of (1S,2R)-(+)-2-Amino-1,2-diphenylethanol.

2-amino-1,2-diphenylethanol is a chiral organic chemical compound with the chemical formula C14H15NO. It is used primarily in asymmetric synthesis as a chiral auxiliary or ligand for enantioselective reactions. You can find detailed UV spectra of (1S,2R)-(+)-2-Amino-1,2-diphenylethanol and information about its various lambda maxima by visiting the following link.

This application describes a normal-phase chiral HPLC method for the separation of (1S,2R)-(+)-2-Amino-1,2-diphenylethanol enantiomers using SIELC’s Cyralis AM chiral column. Cyralis AM is an amylose-based chiral stationary phase (CSP) designed for enantiomeric separations, optical purity testing, chiral impurity analysis, and stereoisomer characterization in pharmaceutical, chemical, agrochemical, and fine chemical applications.

(1S,2R)-(+)-2-Amino-1,2-diphenylethanol can be retained and analyzed using the Cyralis AM stationary phase column. The analysis utilizes an isocratic method with a mobile phase consisting of Hexane, Ethanol, and Ethanolamine. Detection is performed using UV.

Condition

ColumnCyralis AM, 4.6 x 100 mm, 5 µm, 100 A, normal phase
Mobile PhaseHexane/Ethanol/Ethanolamine
Flow Rate1.0 mL/min
DetectionUV 230 nm
Resolution5.33

Description

Class of CompoundsCompound
Analyzing Compounds(1S,2R)-(+)-2-Amino-1,2-diphenylethanol

Application Column

Cyralis AM

Column Diameter: 4.6 mm
Column Length: 100 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: normal phase

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Application Analytes:
(1S,2R)-(+)-2-Amino-1,2-diphenylethanol
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.