HPLC Chiral Separation of 1-phenyl-2-propanol on Cyralis CM Column

HPLC Method for Analysis of 1-Phenyl-2-propanol on Cyralis CM Column by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of 1-Phenyl-2-propanol.

1-phenyl-2-propanol is a chiral secondary alcohol with the chemical formula C9H12O. It is primarily used in chemical research as well as as a fragrance. It has a sweet scent with a honey-like undertone. You can find detailed UV spectra of 1-Phenyl-2-propanol and information about its various lambda maxima by visiting the following link.

This application describes a normal-phase chiral HPLC method for the separation of 1-Phenyl-2-propanol enantiomers using SIELC’s Cyralis CM chiral column. Cyralis CM is a cellulose-based chiral stationary phase (CSP) designed for enantiomeric separations, optical purity testing, chiral impurity analysis, and stereoisomer characterization in pharmaceutical, chemical, agrochemical, and fine chemical applications. For best results, the sample should be prepared fresh for analysis.

1-Phenyl-2-propanol can be retained and analyzed using the Cyralis CM stationary phase column. The analysis utilizes an isocratic method with a mobile phase consisting of Hexane and Ethanol. Detection is performed using UV.

Condition

ColumnCyralis CM, 4.6 x 250 mm, 5 µm, 100 A, dual ended
Mobile PhaseHexane/Ethanol- 99/1%
Flow Rate1.0 mL/min
DetectionUV 250 nm
Resolution1.64

Description

Class of CompoundsAlcohol
Analyzing Compounds1-Phenyl-2-propanol

Application Column

Cyralis CM

Column Diameter: 4.6 mm
Column Length: 250 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
1-Phenyl-2-propanol
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.