Ethyl 4-chloro-3-oxobutanoate

Ethyl 4-chloro-3-oxobutanoate structural formula

CAS Number638-07-3
Molecular FormulaC6H9ClO3
Molecular Weight164.590
InChI KeyOHLRLMWUFVDREV-UHFFFAOYSA-N
LogP0.720
Synonyms
  • Ethyl 4-chloro-3-oxobutanoate
  • Butanoic acid, 4-chloro-3-oxo-, ethyl ester
  • 638-07-3
  • Butanoic acid, 4-chloro-3-oxo-, ethyl ester
  • 4-03-00-01550
  • 4-Chloro acetoethylacetate
  • 4-Chloro-3-oxobutanoic acid ethyl ester
  • 4-Chloro-3-oxobutyric acid ethyl ester
  • 4-Chloroacetoacetate d'ethyle
  • 4-Chloroacetoacetic acid ethyl ester
  • 4-cloroacetoacetato de etilo
  • ACETOACETATE, 4-CHLORO-, ETHYL
  • Acetoacetic acid, 4-chloro-, ethyl ester
  • Ethyl (chloroacetyl)acetate
  • Ethyl 3-oxo-4-chlorobutanoate
  • Ethyl 4-chloro-3-oxobutyrate
  • ethyl 4-chloroacetoacetate
  • Ethyl ?-chloroacetoacetate
  • Ethyl ?-chloroacetoacetate
  • Ethyl-4-chloracetoacetat
  • ?-Chloroacetoacetic acid ethyl ester
  • BRN 1761275
  • EINECS 211-317-0
  • Ethyl gamma-chloroacetoacetate

Applications:

Separation of Ethyl 4-chloro-3-oxobutanoate on Newcrom R1 HPLC column

February 16, 2018
Separation of Ethyl 4-chloro-3-oxobutanoate on Newcrom C18 HPLC column

Ethyl 4-chloro-3-oxobutanoate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Ethyl 4-chloro-3-oxobutanoate
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.