Ethanedioic acid, dimethyl ester

Ethanedioic acid, dimethyl ester structural formula

CAS Number553-90-2
Molecular FormulaC4H6O4
Molecular Weight118.088
  • Ethanedioic acid, dimethyl ester
  • Dimethyl ethanedioate
  • 553-90-2
  • dimethyl oxalate
  • Dimethyloxalat
  • Ethanedioic acid, 1,2-dimethyl ester
  • Methyl oxalate
  • NSC 9374
  • Oxalate de dimethyle
  • oxalato de dimetilo
  • Oxalic acid, dimethyl ester
  • EINECS 209-053-6
  • Oxalic acid dimethyl ester
  • UNII-IQ3Q79344S


Separation of Ethanedioic acid, dimethyl ester on Newcrom R1 HPLC column

May 16, 2018
Separation of Ethanedioic acid, dimethyl ester on Newcrom R1 HPLC column

Ethanedioic acid, dimethyl ester can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Ethanedioic acid, dimethyl ester
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: or by phone: 847-229-2629.