Domperidone structural formula

CAS Number57808-66-9
Molecular FormulaC22H24ClN5O2
Molecular Weight425.920
  • Domperidone
  • 5-Chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one
  • 2H-Benzimidazol-2-one, 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-
  • 57808-66-9
  • Domcolic
  • Domperi 10 DT
  • Evoxin
  • KW 533
  • Mod
  • Motillium
  • Motinorm costi
  • Nomit
  • R 33812
  • domperidone
  • 2H-bencimidazol-2-ona, 5-cloro-1-[1-[3-(2,3-dihidro-2-oxo-1H-bencimidazol-1-il)propil]-4-piperidinil]-1,3-dihidro-
  • 5-24-02-00402
  • 2H-Benzimidazol-2-one, 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-
  • 5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazole-2-one
  • Domperidon
  • domperidona
  • Euciton
  • Gastronorm
  • Motilium
  • Nauzelin
  • Nauzelin Ds
  • NSC 299589
  • Peridon
  • Peridys
  • BRN 0903774
  • 5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone
  • EINECS 260-968-7
  • Domperidonum
  • UNII-5587267Z69


Separation of Domperidone on Newcrom R1 HPLC column

Separation of Domperidone on Newcrom C18 HPLC column

Domperidone can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: or by phone: 847-229-2629.
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to so we can ensure you get optimal results for your compound/s of interest.
Application Analytes: