Difluoroacetic acid

CAS Number381-73-7
Molecular FormulaC2H2F2O2
Molecular Weight96.03
InChI KeyPBWZKZYHONABLN-UHFFFAOYSA-N
LogP0.6
Synonyms
  • DIFLUOROACETIC ACID
  • 381-73-7
  • 2,2-Difluoroacetic acid
  • Acetic acid, difluoro-
  • Difluoressigsaeure
  • 1,1-difluoroacetic acid
  • UNII-ZQK1C95K3N
  • EINECS 206-839-0
  • Difluoroacetic acid, 98%
  • BRN 1098588
  • ZQK1C95K3N
  • Acetic acid, 2,2-difluoro-
  • AI3-28548
  • CHEBI:23716
  • PBWZKZYHONABLN-UHFFFAOYSA-N
  • C2H2F2O2
  • difluoracetic acid
  • Difluoro-acetic acid
  • PubChem12637
  • ACMC-209iya
  • EC 206-839-0
  • Aceticacid, 2,2-difluoro-
  • KSC223M1T
  • CHEMBL453969
  • DTXSID2059932
  • CTK1C3619
  • DTXSID50896814
  • NOCAS_896814
  • KS-000001HW
  • ZINC3861101
  • ANW-28832
  • BBL004035
  • FD2068
  • MFCD00004220
  • STK260852
  • AKOS000118821
  • EF10077
  • MCULE-9791449975
  • BP-10757
  • LS-11716
  • M301
  • SC-25529
  • DB-049243
  • AM20100014
  • CS-0015390
  • D1423
  • FT-0624917
  • EN300-19507
  • K-8339
  • 185700-EP2280012A2
  • Polyfluoroalkyl (linear) carboxylic acids (-CHF2)
  • 3S103873
  • 3S210859
  • Q-102553
  • Q15126139
  • Z1258948133
  • InChI=1/C2H2F2O2/c3-1(4)2(5)6/h1H,(H,5,6

Applications:

HPLC Method for Analysis of Fluoroacetic acid, Difluoroacetic acid and Trifluoroacetic acid on BIST A+ Column

2022-07-07

 

Separation type: Bridge Ion Separation Technology, or BIST™
 

HPLC Method for Analysis of Fluoroacetic acid, Difluoroacetic acid and Trifluoroacetic acid on BIST A+ Column

High Performance Liquid Chromatography (HPLC) Method for Analysis of  Fluoroacetic acid, Difluoroacetic acid and Trifluoroacetic acid

Condition

Column BIST A+, 2.1×100 mm, 3 µm, 100A
Mobile Phase MeCN – 90%
Buffer TMDAP ( N,N,N’,N’-Tetramethyl-1,3-diaminopropane) formate – 5 mM pH 4.0
Flow Rate 0.4 ml/min
Detection Conductivity

 

Description

Class of Compounds
Acids
Analyzing Compounds Fluoroacetic acid, Difluoroacetic acid and Trifluoroacetic acid

Application Column

BIST A+

SIELC Technologies’ BIST™ Columns are a new and simple way to achieve many separations that are traditionally difficult or impossible to achieve with any other HPLC columns. When used with our BIST™ mobile phases, these ion exchange columns can generate very strong retention of analytes that have the same charge polarity as the stationary phase, unlocking new chromatography applications that were previously too difficult to achieve.

Select options
Application Analytes:
Difluoroacetic acid
Fluoroacetic acid
TFA (Trifluoroacetic Acid)
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Bromoacetic and Chloroacetic Acids on Newcrom BH Column

2020-06-17


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Acetic acid and its various chloro- and bromo- forms are widely used in organic chemistry.  Their similar structure makes the acids difficult to retain and separate on reverse-phase HPLC columns.  By using Newcrom BH mixed-mode column which also has ion-exchange properties, the separation can be achieved with a simple isocratic method and relatively short time with a mobile phase of acetonitrile (ACN), water and sulfuric acid (H2SO4) buffer.  UV detection at 200nm.

Condition

Column Newcrom BH, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 10/90%
Buffer H2SO4 – 0.3%
Flow Rate 1.0 ml/min
Detection UV 200nm

Description

Class of Compounds Acid
Analyzing Compounds Acetic acid, Chloroacetic acid,  Bromoacetic acid, Difluoroacetic acid, Unknown, Dichloroacetic acid, Bromochloroacetic acid, Dibromoacetic acid

Application Column

Newcrom BH

The Newcrom columns are a family of reverse phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse phase column with low silanol activity.

Select options
Application Analytes:
Acetic Acid
Bromoacetic acid
Bromochloroacetic acid
Chloroacetic acid
Dibromoacetic acid
Dichloroacetic acid
Difluoroacetic acid
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Acetic acid, Chloroacetic acid, Dichloroacetic acid, Trifluoroacetic acid, Trichloroacetic acid

2020-05-20


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Acetic acid and its substitution derivatives, chloroacetic acid, dichloroacetic acid, trichloroacetic acid, difluoroacetic acid and trifluoroacetic acid, are heavily used as building blocks for more complex compounds in organic synthesis. All six acids can be isocratically separated in HPLC using Newcrom BH mixed-mode column with acetonitrile (ACN) and water mobile phase with sulfuric acid (H2SO4) as buffer and UV detected at 200nm.

Condition

Column Newcrom BH, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 50/50%
Buffer H2SO4 – 0.2%
Flow Rate 1.0 ml/min
Detection UV 200nm

Description

Class of Compounds Acid
Analyzing Compounds Acetic acid, Chloroacetic acid, Dichloroacetic acid, Trifluoroacetic acid (TFA),   Trichloroacetic acid

Application Column

Newcrom BH

The Newcrom columns are a family of reverse phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse phase column with low silanol activity.

Select options
Application Analytes:
Acetic Acid
Chloroacetic acid
Dichloroacetic acid
Difluoroacetic acid
TFA (Trifluoroacetic Acid)
Trichloroacetic acid
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.