Diethyl (2E)-but-2-enedioate

Diethyl (2E)-but-2-enedioate structural formula

CAS Number623-91-6
Molecular FormulaC8H12O4
Molecular Weight172.180
  • Diethyl (2E)-but-2-enedioate
  • 2-Butenedioic acid, diethyl ester, (2E)-
  • 623-91-6
  • 2-Butenedioic acid (2E)-, diethyl ester
  • (2E)-2-Butenedioic acid diethyl ester
  • (E)-2-Butenedioic acid diethyl ester
  • 2-Butenedioic acid (2E)-, 1,4-diethyl ester
  • 2-Butenedioic acid (E)-, diethyl ester
  • 2-Butenedioic acid, (E)-, diethyl ester
  • diethyl fumarate
  • Diethylfumarat
  • Ethyl fumarate
  • Fumarate de diethyle
  • fumarato de dietilo
  • Fumaric acid, diethyl ester
  • NSC 20954
  • Anti-Psoriaticum
  • BRN 0775347
  • trans-2-Butenedioic acid diethyl ester
  • EINECS 210-819-7
  • Diethylester kyseliny fumarove
  • fumaric acid diethyl ester


Separation of Diethyl (2E)-but-2-enedioate on Newcrom R1 HPLC column

February 19, 2018
Separation of Diethyl (2E)-but-2-enedioate on Newcrom C18 HPLC column

Diethyl (2E)-but-2-enedioate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Diethyl (2E)-but-2-enedioate
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: or by phone: 847-229-2629.