Cyproterone acetate

Cyproterone acetate structural formula

CAS Number427-51-0
Molecular FormulaC24H29ClO4
Molecular Weight416.941
InChI KeyUWFYSQMTEOIJJG-FDTZYFLXSA-N
LogP3.75
Synonyms
  • Cyproterone acetate
  • (1R,3aS,3bR,7aR,8aS,8bS,8cS,10aS)-1-Acetyl-5-chloro-8b,10a-dimethyl-7-oxo-1,2,3,3a,3b,7,7a,8,8a,8b,8c,9,10,10a-tetradecahydrocyclopenta[a]cyclopropa[g]phenanthren-1-yl acetate
  • Cyclopenta[a]cyclopropa[g]phenanthren-7(1H)-one, 1-acetyl-1-(acetyloxy)-5-chloro-2,3,3a,3b,7a,8,8a,8b,8c,9,10,10a-dodecahydro-8b,10a-dimethyl-, (1R,3aS,3bR,7aR,8aS,8bS,8cS,10aS)-
  • 427-51-0
  • 3'H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione, 17-(acetyloxy)-6-chloro-1,2-dihydro-, (1?,2?)-
  • 1,2?-Methylene-6-chloro-17?-acetoxy-4,6-pregnadiene-3,20-dione
  • 1,2?-Methylene-6-chloro-pregna-4,6-diene-3,20-dione 17?-acetate
  • 1,2?-Methylene-6-chloro-?4,6-pregnadien-17?-ol-3,20-dione acetate
  • 17-acetate de 6-chloro-1-?,2-?-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione
  • 17-acetato de 6-cloro-1-?,2-?-dihidro-17-hidroxi-3'H-ciclopropa[1,2]pregna-1,4,6-trieno-3,20-diona
  • 17?-Acetoxy-6-chloro-1?,2?-methylenepregna-4,6-diene-3,20-dione
  • 3'H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione
  • 3'H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione, 6-chloro-1?,2?-dihydro-17-hydroxy-, acetate
  • 6-Chlor-1-?,2-?-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-trien-3,20-dion-17-acetat
  • 6-Chloro-1,2?-methylene-17?-hydroxy-?6-progesterone acetate
  • 6-Chloro-1,2?-methylene-6-dehydro-17?-hydroxyprogesterone acetate
  • 6-Chloro-17-hydroxy-1?,2?-methylenepregna-4,6-diene-3,20-dione acetate
  • 6-chloro-1-?,2-?-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione 17-acetate
  • Androcur
  • Cyprostat
  • Cyproterone 17-O-acetate
  • Cyproterone 17?-acetate
  • Cyproviron
  • NSC 81430
  • Pregna-4,6-diene-3,20-dione, 6-chloro-17-hydroxy-1?,2?-methylene-, acetate
  • 17-alpha-Acetoxy-6-chloro-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dione
  • 6-Chloro-17-hydroxy-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dione acetate
  • 6-Chloro-1,2-alpha-methylene-6-dehydro-17-alpha-hydroxyprogesterone acetate
  • 6-Chloro-delta-6-1,2alpha-methylene-17alpha-hydroxyprogesterone acetate
  • 6-Chloro-1,2-alpha-methylene-17-alpha-hydroxy-delta(sup 6)-progesterone acetate
  • 6-Chloro-delta(sup 6)-1,2-alpha-methylene-17-alpha-hydroxyprogesterone acetate
  • Cyproteron acetate
  • Cyproteron-R acetate
  • Cyproterone 17alpha-acetate
  • EINECS 207-048-3
  • 1,2-alpha-Methylene-6-chloro-pregna-4,6-diene-3,20-dione 17-alpha-acetate
  • 1,2-alpha-Methylene-6-chloro-delta(sup 6)-17-alpha-hydroxyprogesterone acetate
  • 1,2-alpha-Methylene-6-chloro-(sup 4,6)-pregnadiene-17-alpha-ol-3,20-dione 17-alpha-acetate
  • NSC-81430
  • Pregna-4,6-diene-3,20-dione, 6-chloro-17-hydroxy-1-alpha,2-alpha-methylene-, acetate
  • 6-Chlor-delta(sup 6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteronacetat
  • UNII-4KM2BN5JHF

Applications:

Separation of Cyproterone acetate on Newcrom R1 HPLC column

February 16, 2018
Separation of Cyproterone acetate on Newcrom C18 HPLC column

Cyproterone acetate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Cyproterone acetate
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.