Chlorpheniramine

Chlorpheniramine structural formula

CAS Number132-22-9
Molecular FormulaC16H19ClN2
Molecular Weight274.791
InChI KeySOYKEARSMXGVTM-UHFFFAOYSA-N
LogP3.38
Synonyms
  • Chlorpheniramine
  • 3-(4-Chlorophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine
  • 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-
  • 132-22-9
  • 2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-
  • (.+-.)-Chloropheniramine
  • (.+-.)-Chlorpheniramine
  • 1-(p-Chlorophenyl)-1-(2'-pyridyl)-3-(N,N-dimethylamino)-propane
  • 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane
  • 2-[p-Chloro-α-[2-(dimethylamino)ethyl]benzyl]pyridine
  • 3-(p-Chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine
  • 4-Chloropheniramine
  • Allergican
  • Chloropheniramine
  • Chlorophenylpyridamine
  • Chloroprophenpyridamine
  • Chlorphenamin
  • Chlorphenamine
  • Chlorprophenpyridamine
  • clorfenamina
  • dl-1-(p-Chlorophenyl)-1-(2-pyridyl)-3-(dimethylamino)propane
  • PYRIDINE, 2-(3-AMINOPROP-1-YL)-, γ-(4-CHLOROPHENYL)-N,N-DIMETHYL-
  • Pyridine, 2-[p-chloro-α-[2-(dimethylamino)ethyl]benzyl]-
  • RS-Chlorpheniramine
  • γ-(4-Chlorophenyl)-γ-(2-pyridyl)propyldimethylamine
  • 2-(p-Chloro-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine
  • 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamine
  • Chloropiril
  • Chlorpheniraminum
  • EINECS 205-054-0
  • Chlorphenaminum
  • UNII-3U6IO1965U
  • chlorophenylpyridamine
  • clorfeniramina
  • gamma-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine
  • gamma-(4-chlorophenyl)-gamma-(2-pyridyl)propyldimethylamine
  • 42882-96-2
  • 46970-45-0

Applications:

HPLC Separation of Drugs in Tylenol Cold and Cough Remedies

August 22, 2008

Components of Tylenol Cold and Cough Remedy are separated on Obelisc R mixed-mode column. Method can be used to determine compounds in various cough and cold compositions. Neutral (acetaminophen), basic (chlorpheniramine, dextromethorphan and pseudoephedrine) and acidic (maleic acid/Maleate) components are analyzed with perfect peak shape and retention control. Method can be used in production, QC/QA and biological studies for quantitation of various components in pharmaceutical formulations (Advil, Tylenol, Dimetapp, Robitussin, NyQuil, etc)

Condition
Column Obelisc R, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN
Buffer AmFm
Flow Rate 1.0 ml/min
Detection UV, 270 nm

 

 

Description
Class of Compounds
 Drug, Analgetic, Acid, Hydrophilic, Ionizable, Neutral, Basic
Analyzing Compounds Maleate, Chlorpheniramine, Dextromethorphan, Pseudoephedrine,  Acetaminophen

Application Column

Obelisc R

SIELC has developed the Obelisc™ columns, which are mixed-mode and utilize Liquid Separation Cell technology (LiSC™). These cost-effective columns are the first of their kind to be commercially available and can replace multiple HPLC columns, including reversed-phase (RP), AQ-type reversed-phase, polar-embedded group RP columns, normal-phase, cation-exchange, anion-exchange, ion-exclusion, and HILIC (Hydrophilic Interaction Liquid Chromatography) columns. By controlling just three orthogonal method parameters - buffer concentration, buffer pH, and organic modifier concentration - users can adjust the column properties with pinpoint precision to separate complex mixtures.

Select options
Application Analytes:
Acetaminophen (Paracetamol)
Chlorpheniramine
Dextromethorphan
Maleate
Pseudoephedrine (PSE)
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.