Chlorpheniramine maleate

Chlorpheniramine maleate structural formula

CAS Number113-92-8
Molecular FormulaC20H23ClN2O4
Molecular Weight390.860
InChI KeyDBAKFASWICGISY-BTJKTKAUSA-N
LogP3.11
Synonyms
  • Chlorpheniramine maleate
  • 3-(4-Chlorophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-aminium (2Z)-3-carboxyprop-2-enoate
  • 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1)
  • 113-92-8
  • 2-Pyridinepropanamine, ?-(4-chlorophenyl)-N,N-dimethyl-,
  • (.+-.)-Chlorpheniramine maleate
  • 1-Parachlorophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate
  • 1-p-Chlorophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate
  • 2-[p-chloro-?-[2-(dimethylamino)ethyl]benzyl]pyridine maleate (1:1)
  • Allergin
  • Allergisan
  • Anallerge 4
  • Antagonate
  • Carbinoxamide maleate
  • Chlorophenamine
  • Chloroprophenpyridamine maleate
  • chlorphenamine hydrogen maleate
  • Chlorphenamine maleate
  • Chlorphenaminhydrogenmaleat
  • Chlorprophenpyridamine maleate
  • Chlor-Trimeton
  • Chlor-Tripolon
  • Cloropiril
  • C-Meton
  • dl-Chlorpheniramine maleate
  • hidrogenomaleato de clorfenamina
  • Histadur
  • Histadur dura-tabs
  • Histaspan
  • Hydrogenomaleate de chlorphenamine
  • Ibioton
  • Lorphen
  • Neorestamin
  • Pirafene
  • Piriton
  • Puermin
  • Pyridamal 100
  • Pyridine, 2-[p-chloro-?-[2-(dimethylamino)ethyl]benzyl]-, maleate (1:1)
  • Synistamin
  • Teldrin
  • M.P. chlorcaps T.D.
  • Allerclor
  • Chlormene
  • dl-2-(p-Chloro-alpha-2-(dimethylamino)ethylbenzyl)pyridine maleate
  • 1-(N,N-Dimethylamino)-3-(p-chlorophenyl-3-alpha-pyridyl)propane maleate
  • EINECS 204-037-5
  • NCI-C55265
  • Pyridamal-100
  • Chlor-Trimeton Allergy
  • Efidac 24 chlorpheniramine maleate
  • Kloromin
  • Phenetron
  • 1-(p-Chlorphenyl)-1-(2-pyridyl)-3-dimethylaminopropan maleat
  • Phenalin
  • UNII-V1Q0O9OJ9Z
  • Medique chlorphen
  • Chlor-trimeton (TN)
  • Teldrin (TN)
  • 7054-11-7

Applications:

HPLC Method for Analysis of Chlorpheniramine Maleate on BIST B+

November 30, 2022

HPLC Method for Analysis of Chlorpheniramine Maleate on BIST B+ by SIELC Technologies.

Separation type: Bridge Ion Separation Technology, or BIST™ by SIELC Technologies

HPLC Method for Analysis of Chlorpheniramine Maleate on BIST B+ Column
HPLC Method for Analysis of Chlorpheniramine Maleate on BIST B+ by SIELC Technologies.

High Performance Liquid Chromatography (HPLC) Method for Analyses of Chlorpheniramine Maleate

Chlorpheniramine Maleate is a popular antihistamine used to provide relief from the symptoms of allergies, hay fever, and the common cold. Using SIELC’s newly introduced BIST™ method, Chlorpheniramine Maleate, which separates in water, can be retained on a positively-charged anion-exchange BIST™ B column. There are two keys to this retention method: 1) a multi-charged, negative buffer, such as Sulfuric acid (H2SO4), which acts as a bridge, linking the positively-charged analytes to the positively-charged column surface and 2) a mobile phase consisting mostly of organic solvent (such as MeCN) to minimize the formation of a solvation layer around the charged analytes. Using this new and unique analysis method, Chlorpheniramine Maleate can be separated, retained, and UV detected at 210 nm and 275 nm.


Condition

ColumnBIST B+, 4.6×50 mm, 5 µm, 100A
Mobile PhaseMeCN – 85%
BufferH2SO4 – 0.2%
Flow Rate1.0 ml/min
DetectionUV 210, 275 nm
Peak Retention Time2.9 min

Description

Class of CompoundsDrug
Analyzing CompoundsChlorpheniramine Maleate

Application Column

BIST B

BIST™ columns offer a unique and effective way to achieve separations that were traditionally challenging or even impossible with other HPLC columns. With the use of a special mobile phase, these ion exchange columns provide very strong retention for analytes with the same charge polarity as the stationary phase, unlocking new chromatography applications. What makes BIST™ columns stand out is their proprietary surface chemistry, which results in superior selectivity, resolution, and sensitivity. These columns offer a simple, efficient solution for a variety of analytical challenges, making them an excellent choice for researchers and analysts across many different fields. To learn more about the technology that powers BIST™ columns and to explore related applications, check out https://BIST.LC.

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BIST B+

BIST™ columns offer a unique and effective way to achieve separations that were traditionally challenging or even impossible with other HPLC columns. With the use of a special mobile phase, these ion exchange columns provide very strong retention for analytes with the same charge polarity as the stationary phase, unlocking new chromatography applications. What makes BIST™ columns stand out is their proprietary surface chemistry, which results in superior selectivity, resolution, and sensitivity. These columns offer a simple, efficient solution for a variety of analytical challenges, making them an excellent choice for researchers and analysts across many different fields. To learn more about the technology that powers BIST™ columns and to explore related applications, check out https://BIST.LC.

Select options
Application Analytes:
Chlorpheniramine maleate
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Chlorpheniramine maleate on Newcrom R1 HPLC column

February 16, 2018
Separation of Chlorpheniramine maleate on Newcrom C18 HPLC column

Chlorpheniramine maleate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Chlorpheniramine maleate
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.