Clodronic acid

Clodronic acid structural formula

CAS Number10596-23-3
Molecular FormulaCH4Cl2O6P2
Molecular Weight244.881
InChI KeyACSIXWWBWUQEHA-UHFFFAOYSA-N
LogP-0.897
Synonyms
  • Clodronic acid
  • (Dichloromethylene)bis(phosphonic acid)
  • Phosphonic acid, (dichloromethylene)bis-
  • 10596-23-3
  • Phosphonic acid, (dichloromethylene)bis-
  • (Dichloromethylene)bis[phosphonic acid]
  • acide clodronique
  • acido clodronico
  • Clodronate
  • Clodroninsaure
  • Dichloromethylenediphosphonic acid
  • Methanedichlorodiphosphonic acid
  • Phosphonic acid, (dichloromethylene)di-
  • Phosphonic acid, P,P'-(dichloromethylene)bis-
  • BRN 1876367
  • EINECS 234-212-1
  • Dichlormethylen-bis(phosphonsaeure)
  • Acidum clodronicum
  • UNII-0813BZ6866
  • (Dichloro-phosphono-methyl)-phosphonic acid
  • (dichloromethylene)bisphosphonic acid
  • (dichloromethylene)diphosphonic acid
  • clodronsaeure
  • dichloromethylene-1,1-bisphosphonic acid
  • dichloromethylene-1,1-diphosphonic acid
  • dichloromethylidene diphosphonate

Applications:

Separation of Clodronic acid on Newcrom R1 HPLC column

May 16, 2018
Separation of Clodronic acid on Newcrom R1 HPLC column

Clodronic acid can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Clodronic acid
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.