Chlorhexidine diacetate

Chlorhexidine diacetate structural formula

CAS Number56-95-1
Molecular FormulaC26H38Cl2N10O4
Molecular Weight625.560
InChI KeyWDRFFJWBUDTUCA-UHFFFAOYSA-N
LogP2.49
Synonyms
  • Chlorhexidine diacetate
  • Acetic acid--N,N''''-hexane-1,6-diylbis[N'-(4-chlorophenyl)triimidodicarbonic diamide] (2/1)
  • Imidodicarbonimidic diamide, N,N''''-1,6-hexanediylbis[N'-(4-chlorophenyl)-, acetate (1:2)
  • 56-95-1
  • 10,040 Diacetate
  • Bactigras
  • 1,6-Bis(5-(p-chlorophenyl)biguandino)hexane diacetate
  • 1,6-Bis(p-chlorophenylbiguanido)hexane diacetate
  • Bis(p-chlorophenyldiguanidohexane) diacetate
  • Caswell No. 481E
  • Chlorhexidine acetate
  • Chlorohexidine diacetate
  • 1,6-Di(4'-chlorophenyldiguanidino)hexane diacetate
  • EINECS 200-302-4
  • EPA Pesticide Chemical Code 045502
  • 1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide) diacetate
  • 1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide) diacetate
  • 1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide)diacetate
  • Hibitane diacetate
  • NSC 526936
  • UNII-5908ZUF22Y
  • 36466-50-9

Applications:

Separation of Chlorhexidine diacetate on Newcrom R1 HPLC column

February 19, 2018
Separation of Chlorhexidine diacetate on Newcrom C18 HPLC column

Chlorhexidine diacetate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Chlorhexidine diacetate
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.