alpha-Lipoic acid

alpha-Lipoic acid structural formula

CAS Number1077-28-7
Molecular FormulaC8H14O2S2
Molecular Weight206.321
InChI KeyAGBQKNBQESQNJD-UHFFFAOYSA-N
LogP2.53
Synonyms
  • alpha-Lipoic acid
  • 5-(1,2-Dithiolan-3-yl)pentanoic acid
  • 1,2-Dithiolane-3-pentanoic acid
  • 1077-28-7
  • Thioctic acid
  • 5-19-07-00237
  • 1,2-Dithiolane-3-pentanoic acid
  • (.+-.)-Lipoic acid
  • (.+-.)-Thioctic acid
  • (.+-.)-?-Lipoic acid
  • (RS)-Lipoic acid
  • (RS)-?-Lipoic acid
  • 1,2-Dithiolane-3-pentanoic acid, (.+-.)-
  • 1,2-Dithiolane-3-valeric acid
  • 1,2-Dithiolane-3-valeric acid, (.+-.)-
  • 5-(1,2-Dithiolan-3-yl)pentanoic acid
  • 5-(1,2-Dithiolan-3-yl)valeric acid
  • 5-(Dithiolan-3-yl)valeriansaeure
  • 5-(dithiolan-3-yl)valeric acid
  • 6,8-Thioctic acid
  • 6-Thioctic acid
  • Acide 5-(dithiolan-3-yl)valerique
  • acide 5-(dithiolanne-3-yl)valerique
  • acido 5-(ditiolan-3-il)valerico
  • Alipure
  • Biletan
  • DL-6,8-Thioctic acid
  • DL-6-Thioctic acid
  • dl-Lipoic acid
  • dl-Thioctic acid
  • DL-?-Lipoic acid
  • Espa-lipon
  • Liposan
  • Lipothion
  • NSC 628502
  • NSC 90788
  • Protogen A
  • Pyruvate oxidation factor
  • Thioctacid
  • Thioctsan
  • Thiotacid
  • Tioctacid
  • Tioctidasi
  • Tioctidasi acetate replacing factor
  • ?-Liponic acid
  • BRN 0081853
  • DL-1,2-Dithiolane 3-valeric acid
  • (+-)-1,2-Dithiolane-3-pentanoic acid
  • DL-1,2-Dithiolane-3-valeric acid
  • EINECS 214-071-2
  • DL-alpha-Lipoic acid
  • Rac-lipoate
  • Thioctic acid dl-form
  • DL-1,2-Dithiolan-3-valeriansaeure
  • UNII-73Y7P0K73Y
  • 6,8-Dithiooctanoic acid
  • (+-)-alpha-Lipoic acid
  • (+-)-Lipoic acid
  • (+-)-Thioctic acid
  • (RS)-alpha-Lipoic acid
  • alpha-lipon 300
  • alpha-Liponic acid
  • EINECS 200-534-6
  • BRN 0122410
  • 5-(3-dithiolanyl)pentanoic acid
  • 5-(dithiolan-3-yl)pentanoic acid
  • 5-[3-(1,2-dithiolanyl)]pentanoic acid
  • 6,8-thiotic acid
  • 6-thiotic acid
  • Acetate-replacing factor
  • Lipoic acid
  • Thioctansaeure
  • Thioctsaeure
  • Thioktsaeure
  • alpha-Liponsaeure
  • liponic acid
  • 27779-68-6
  • 62-46-4

Applications:

Separation of alpha-Lipoic acid on Newcrom R1 HPLC column

February 19, 2018
Separation of alpha-Lipoic acid on Newcrom C18 HPLC column

alpha-Lipoic acid can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
alpha-Lipoic acid
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.