GLU (L-Glutamic acid)

L-Glutamic acid

CAS Number56-86-0
Molecular FormulaC5H9NO4
Molecular Weight147.13
InChI KeyWHUUTDBJXJRKMK-VKHMYHEASA-N
LogP-2.77
Synonyms
  • (2S)-2-Aminopentanedioic acid
  • (S)-(+)-Glutamic acid
  • (S)-2-Aminopentanedioic acid
  • (S)-Glutamic acid
  • 1-Aminopropane-1,3-dicarboxylic acid
  • 2-AMINOGLUTARIC ACID
  • 2-Aminopentanedioic acid
  • Acide glutamique
  • acido glutamico
  • Aciglut
  • AMINOGLUTARIC ACID, L-
  • Glusate
  • Glutacid
  • Glutamic acid, L-
  • Glutamicol
  • Glutamidex
  • Glutaminol
  • GLUTAMINSAEURE
  • Glutaminsaure
  • Glutaton
  • L-(+)-Glutamic acid
  • l-Glutaminic acid
  • L-Gutamic acid
  • L-?-AMINOGLUTARIC ACID
  • NSC 143503
  • Pentanedioic acid, 2-amino-, (S)-
  • ?-Aminoglutaric acid
  • ?-Glutamic acid
  • Acidum glutaminicum
  • L-2-Aminoglutaric acid
  • 2-Aminopentanedioic acid, (S)-
  • EINECS 200-293-7
  • FEMA No. 3285
  • Glutamate, L-
  • Glutamic acid (H-3)
  • Glutamic acid, (S)-
  • D-Glutamiensuur
  • EPA Pesticide Chemical Code 374350
  • Acidum glutamicum
  • UNII-3KX376GY7L FDA Registry Number
  • (2S)-2-Aminopentanedioate
  • (S)-(+)-Glutamate
  • (S)-2-Aminopentanedioate
  • (S)-Glutamate
  • 1-Amino-propane-1,3-dicarboxylate
  • 1-Amino-propane-1,3-dicarboxylic acid
  • 1-Aminopropane-1,3-dicarboxylate
  • 2-Aminoglutarate
  • 2-Aminopentanedioate
  • 2-Aminopentanedioic acid
  • Aminoglutarate
  • Aminoglutaric acid
  • Glt
  • Glut
  • Glutamate
  • Glutaminate
  • Glutaminic acid
  • L-(+)-Glutamate
  • L-Glu
  • L-Glutamate
  • L-Glutaminate
  • L-Glutaminsaeure
  • L-a-Aminoglutarate
  • L-a-Aminoglutaric acid
  • L-alpha-Aminoglutarate
  • L-alpha-Aminoglutaric acid
  • a-Aminoglutarate
  • a-Aminoglutaric acid
  • a-Glutamate
  • a-Glutamic acid
  • alpha-Aminoglutarate
  • alpha-Aminoglutaric acid
  • alpha-Glutamate
  • alpha-Glutamic acid

Applications:

HPLC Method for Separation of Ibotenic Acid and Glutamic Acid on Primesep A Column

February 28, 2023

HPLC Method for Separation of Ibotenic Acid and Glutamic Acid on Primesep A by SIELC Technologies

Separation type: Liquid Chromatography Mixed-mode

HPLC Method for Separation of Ibotenic Acid and Glutamic Acid on Primesep A by SIELC Technologies
Method for Separation of Ibotenic Acid and Glutamic Acid on Primesep A by SIELC Technologies

Ibotenic acid is a physchoactive NDMA and metabotropic glutamate receptor agonist with neurotoxic properties. These structurally similar psychoactive drugs can be retained, separated, and analyzed on a mixed-mode Primesep A column with a mobile phase consisting of water, Acetonitrile (MeCN), and Phosphoric acid (H3PO4). This analytical method can be UV detected at 210 nm with high resolution and peak symmetry.

High Performance Liquid Chromatography (HPLC) Method for Analysis of  Ibotenic Acid and Glutamic Acid

Condition

ColumnPrimesep A, 4.6 x 150 mm, 5 µm, 100 A
Mobile PhaseMeCN/H2O – 5/95%
BufferH3PO4 – 0.1%
Flow Rate1.0 ml/min
DetectionUV 210 nm
Peak Retention Time3.22 min, 10.52 min

Description

Class of CompoundsAcid
Analyzing CompoundsIbotenic Acid, Glutamic Acid

Application Column

Primesep A

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A

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Application Analytes:
D-Glutamic acid
GLU (L-Glutamic acid)
Glutamic Acid
Ibotenic acid
L-Glutamic acid hydrochloride
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Mixture of Non-Essential Amino Acids

March 11, 2019

 

Condition

Column Primesep 100, 4.6×250 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 20/80%
Buffer H3PO4 – 0.1%
Flow Rate 1.0 ml/min
Detection UV, 200 nm

 

Description

Class of Compounds
Drug, Acid, Hydrophilic, Ionizable, Vitamin, Supplements, Amino acid
Analyzing Compounds L-Aspartic Acid (Asp/D), L-Serine (Ser/S), L-Glutamic Acid Glu/E), L-Alanine Ala/A)

 

Application Column

Primesep 100

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

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Application Analytes:
Amino Acids
Aspartic Acid
D-Alanine
DL-Alanine
GLU (L-Glutamic acid)
Glutamic Acid
Serine
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of GABA and GLU

August 22, 2008

Amino acids are building blocks for peptides and proteins; they are used in various supplement formulations and as starting reagents in chemistry to introduce chirality. GABA and GLU are used to enhance growth of specified plants, prevent development of powdery mildew on grapes, and suppress certain other plant diseases. L-Glutamic acid is one of the major amino acids naturally found in plant and animal proteins, and GABA helps to maintain normal brain function. Both amino acids behave as neurotransmitters. All amino acids have both basic and acidic groups. Depending on pH amino acids can be basic, acidic or zwitter-ionic. Due to the polar nature of underivatized amino acids, analysis is a very challenging task. Derivatization and ion-pairing reagents are used to provide retention of amino acids. Simple method is developed on Primesep 100 column using combination of acetonitrile/water with phosphoric acid as a mobile phase. Method uses UV detection. Amino acids are well retained without use of ion-pairing reagents. Fast reliable method can be developed for all underivatized natural and synthetic amino acids.

Condition

Column Primesep 100, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O
Buffer H3PO4
Flow Rate 1.0 ml/min
Detection UV, 215 nm

 

Description

Class of Compounds
Drug, Acid, Hydrophilic, Ionizable, Vitamin, Supplements, Amino acid
Analyzing Compounds GABA, Glu

 

Application Column

Primesep 100

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
GLU (L-Glutamic acid)
gamma-Aminobutyric Acid (GABA)

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.