Ethylamine

CAS Number	75-04-7
Molecular Formula	C2H7N
Molecular Weight	45.085
InChI Key	QUSNBJAOOMFDIB-UHFFFAOYSA-N
LogP	-0.130
Synonyms	Ethanamine 75-04-7 Monoethylamine 1-Aminoethane AETHYLAMIN Aminoethane Ethylamin Ethylamine etilamina n-Ethylamine UN 1036 UN 2270 EINECS 200-834-7 UNII-YG6MGA6AT5 Aethylamine Ethyl amine Ethylamine solution Etyloamina 43031-21-6 85404-16-6 85404-22-4

Applications:

Mixed-Mode Retention and Separation of Ammonia, Primary and Secondary Amines on Primesep A Column

December 6, 2007

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Separation type: Liquid Chromatography Mixed-mode

Ammonia, primary and secondary amines are common compounds used as building blocks in organic synthesis. Derivatives of these compounds are used in agriculture, pharmaceutical, and chemical manufacturing. All compounds in this application are basic and hydrophilic in nature. Problems in analysis include poor peak shape, lack of retention on C18 columns, and absence of chromophores in ammonia, primary and secondary amines. Analysis of hydrophilic amines requires derivatization to provide hydrophobicity/retention and UV activity, ion-pairing reagents to provide retention. Presence of residual silanols will affect peak shape. Ammonia, methylamine, morpholine, ethylamine, diethylamine, and butylamine can be analyzed on a Primesep A HPLC column with trifluoroacetic acid in the mobile phase. Compounds in the mixture can be monitored by ELSD.

Application Column

Primesep A

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options

Ammonia
Butylamine
Diethylamine
Ethylamine
Methylamine
Morpholine

ELSD Detection

SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Simple Amines and Ammonia

October 4, 2006

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Primesep A separates ammonia and simple amines (butylamine, diethylamine, ethylamine, methylamine and morpholine) by cation exchange and reversed phase. Primesep A has an embedded strong anionic functional group which helps retain cations by polar and ion-exchange mechanisms. Excellent peak shape results with a mass spec compatible mobile phase of water, acetonitrile (MeCN, ACN) and trifluoracetic acid (TFA) with evaporative light scattering detection (ELSD).