| CAS Number | 13614-98-7 |
|---|---|
| Molecular Formula | C23H28ClN3O7 |
| Molecular Weight | 493.941 |
| InChI Key | GLMUAFMGXXHGLU-VQAITOIOSA-N |
| LogP | -0.139 |
| Synonyms |
|
Applications:
HPLC Method For Analysis Of Minocycline on Primesep 100 column
August 9, 2021
Separation type: Liquid Chromatography Mixed-mode
High Performance Liquid Chromatography (HPLC) Method for Analysis of Minocycline hydrochloride
Minocycline is in a class of medications called tetracycline antibiotics. It works in treatment of infections by preventing the growth and spread of bacteria. Minocycline can be retained on the Primesep 100 mixed-mode column using an isocratic analytical method with a simple mobile phase of water, acetonitrile (MeCN, ACN), and sulphuric acid (H2SO4) buffer. The analysis method can be UV detected at 270 nm.
| Column | Primesep 100, 4.6×150 mm, 5 µm, 100A |
| Mobile Phase | MeCN/H2O – 50/50% |
| Buffer | H2SO4 – 0.5% |
| Flow Rate | 1.0 ml/min |
| Detection | UV, 270 nm |
| Class of Compounds |
Drug, Antibiotics |
| Analyzing Compounds | Minocycline hydrochloride |
Application Column
Primesep 100
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
Select options
HPLC Method For Analysis Of Minocycline hydrochloride on Newcrom R1 Column
May 22, 2018
Minocycline hydrochloride is a tetracycline antibiotic used to treat a wide variety of bacterial infections as well as treatment of acne vulgaris
| Column | Newcrom R1, 3.2×100 mm, 5 µm, 100A |
| Mobile Phase | MeCN/H2O – 5/95% |
| Buffer | TEAPh – 20 mM, pH 2.0 |
| Flow Rate | 0.5 ml/min |
| Detection | UV, 270 nm |
| Class of Compounds |
Drug, Antibiotics |
| Analyzing Compounds | Minocycline hydrochloride |
Application Column
Newcrom R1
The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.
Select options
