Imatinib mesylate

Imatinib mesylate structural formula

CAS Number220127-57-1
Molecular FormulaC30H35N7O4S
Molecular Weight589.720
InChI KeyYLMAHDNUQAMNNX-UHFFFAOYSA-N
LogP2.84
Synonyms
  • Imatinib mesylate
  • Methanesulfonic acid--4-[(4-methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide (1/1)
  • Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-, methanesulfonate (1:1)
  • 220127-57-1
  • STI571
  • Imatinib mesilate
  • Gleevec
  • Shantinib
  • UNII-8A1O1M485B
  • imatinib methansulfonate
  • imatinib monomesylate
  • imatinib methanesulfonate

Applications:

Determination Imatinib Mesylate on Obelisc R Column

February 10, 2021

HPLC Method for Imatinib mesylate on Obelisc R by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of Imatinib mesylate.

Imatinib mesylate is a classified as a signal transduction inhibitor with the chemical formula C29H31N7O. It is an oral targeted therapy medication that is effective in treating chronic myeloid leukemia and metastatic gastrointestinal stromal tumors. Commercial versions of the drug were a topic of controversy when cancer specialists published a letter condemning the high costs of cancer treatments.

Imatinib mesylate can be retained on an Obelisc R column, which has both positive and negative ion-pairs embedded in the stationary phase, allowing for the fine tuning and separation of a wide range of compounds with different ionic properties. Imatinib mesylate can be determined isocratically using a simple MS-compatible mobile phase of acetonitrile (ACN) and water with Ammonium Formate (AmFm) buffer and detected by UV at 270nm, ELSD, CAD or LC/MS.

Condition
Column Obelisc R, 4.6 x 150 mm, 5 µm, 100 A, dual ended
Mobile Phase MeCN -50%
Buffer Ammonium Formate pH 3.0 – 50 mM
Flow Rate 1.0 ml/min
Detection UV 270nm

 

Description
Class of Compounds
  Drug
Analyzing Compounds Imatinib mesylate

 

Application Column

Obelisc R

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

Add to cart
Application Analytes:
Imatinib mesylate
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Imatinib mesylate on Newcrom R1 HPLC column

May 16, 2018
Separation of Imatinib mesylate on Newcrom R1 HPLC column

Imatinib mesylate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Imatinib mesylate
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us before ordering the column as there may be a more suitable column alternative by either e-mail: support@sielc.com or by phone: 847-229-2629.