Aspirin

Aspirin structural formula

CAS Number50-78-2
Molecular FormulaC9H8O4
Molecular Weight180.159
InChI KeyBSYNRYMUTXBXSQ-UHFFFAOYSA-N
LogP1.19
Synonyms
  • Aspirin
  • 2-(Acetyloxy)benzoic acid
  • Benzoic acid, 2-(acetyloxy)-
  • 50-78-2
  • Acetylsalicylic acid
  • 4-10-00-00138
  • Benzoic acid, 2-(acetyloxy)-
  • 2-(ACETYLOXYBENZOIC) ACID
  • 2-(Acetyloxy)benzoic acid
  • 2-Acetoxybenzoic acid
  • 2-Carboxyphenyl acetate
  • A.S.A. Empirin
  • Acenterine
  • Acetard
  • Aceticyl
  • Acetilum acidulatum
  • Acetisal
  • Acetonyl
  • Acetophen
  • Acetosal
  • Acetosalic acid
  • Acetosalin
  • Acetylin
  • Acetylsal
  • ACETYLSALICYLSAEURE
  • Acetyonyl
  • Acetysal
  • Acide O-acetylsalicylique
  • acido O-acetilsalicilico
  • Acidum acetylsalicylicum
  • Acimetten
  • Acylpyrin
  • Albyl E
  • Asaflow
  • Asagran
  • Asatard
  • Ascolong
  • Ascriptin
  • Aspalon
  • Aspergum
  • Aspirdrops
  • Aspirina 03
  • Aspirin-Direkt
  • Aspro Clear
  • Aspropharm
  • Asteric
  • Benaspir
  • Bialpirina
  • Bialpirinia
  • Cardioaspirina
  • Claradin
  • Colfarit
  • Contrheuma Retard
  • Coricidin
  • Coricidin D
  • Dolean pH 8
  • Dominal
  • Duramax
  • Easprin
  • Ecotrin
  • Empirin
  • Endosprin
  • Endydol
  • Entericin
  • Enterophen
  • Enterosarine
  • Entrophen
  • Gelprin
  • Globentyl
  • Globoid
  • Helicon
  • Idragin
  • Istopirin
  • Kapsazal
  • Magnecyl
  • Measurin
  • Medisyl
  • Melhoral
  • Micristin
  • Miniasal
  • Neuronika
  • NSC 27223
  • NSC 406186
  • Nu-seals
  • o-(Acetyloxy)benzoic acid
  • o-Acetoxybenzoic acid
  • O-acetylsalicylic acid
  • O-Acetylsalicylsaure
  • o-Carboxyphenyl acetate
  • Persistin
  • Polopiryna
  • Rheumintabletten
  • Rhodine
  • Rhodine 2312
  • Rhodine NC RP
  • Salacetin
  • Salcetogen
  • Saletin
  • Salicylic acid acetate
  • SALICYLIC ACID, ACETYL-
  • Salospir
  • Salycylacetylsalicylic acid
  • Solpyron
  • Temperal
  • Triple-sal
  • Trombyl
  • Zorprin
  • Acetilsalicilico
  • Acetylsalicylate
  • Acetylsalycilic acid
  • Aspirine
  • Bi-prin
  • BRN 0779271
  • Cemirit
  • Clariprin
  • Decaten
  • Delgesic
  • EINECS 200-064-1
  • Enterosarein
  • Pirseal
  • Rheumin tabletten
  • Solfrin
  • Spira-Dine
  • Bayer Extra Strength Aspirin for Migraine Pain
  • 8-hour Bayer
  • Acetylsalicylsaure
  • Acide acetylsalicylique
  • Acido acetilsalicilico
  • Acido O-acetil-benzoico
  • Kyselina 2-acetoxybenzoova
  • Kyselina acetylsalicylova
  • Aspir-Mox
  • UNII-R16CO5Y76E
  • Asaphen
  • AspirinTest2
  • 2-(Acetyloxy)benzoate
  • 2-Acetoxybenzoate
  • ASA
  • Acetol
  • Acetysal
  • Acetysalicylic acid
  • Azetylsalizylsaeure
  • Bufferin
  • Caprin
  • Ecolen
  • O-(Acetyloxy)benzoate
  • O-Acetoxybenzoate
  • Pharmacin
  • Premaspin
  • Solprin
  • Solprin acid
  • Solpyron
  • Tasprin
  • Toldex
  • Triaminicin
  • acide 2-(acetyloxy)benzoique
  • 11126-35-5
  • 11126-37-7
  • 2349-94-2
  • 26914-13-6
  • 98201-60-6

Applications:

USP Methods for the Analysis of an Analgesic Mixture Using the Legacy L1 Column

2012-06-21

 

Application Notes: Acetametaphin, aspirin, and caffeine tablets contain not less than 90 percent and not more than 110 percent of the labeled amounts if acetametaphin, asprin, and caffeine according the USP methods. USP HPLC method for separation of acetaminophen, aspirin and caffeine was developed on Legacy L1 column according to US Pharmacopeia methodology. L1 classification is assigned to reversed-phase HPLC column contains C18 ligands. Support for the material is a spherical silica gel with particles size 3-10 um and pore size of 100-120A. Resolution between critical pairs corresponds to rules and specifications of USP.

Application Columns: Legacy L1 C18 HPLC column

Application compounds: Acetaminophen, Aspirin, Caffeine, benzoic acid, and salicylic acid

Mobile phase: MeOH/H2O/AcOH 28/69/3

Detection technique: UV

Reference: USP30: NF35

Condition

Column Legacy L1, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeOH/H2O/AcOH 28/69/3
Buffer AcOH
Flow Rate 1.0 ml/min
Detection UV, 270 nm

 

Description

Class of Compounds
Drug, Acid, Hydrophobic, Ionizable
Analyzing Compounds Acetaminophen, Caffeine, Aspirin, Benzoic acid, Salicylic acid

 

SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.
SIELC Legacy L1 HPLC column

Legacy L1

SIELC’s family of Legacy columns is based on United States Pharmacopeia’s (USP) published chromatographic methods and procedures. A plethora of brands have columns used in USP reference standards and methods, and USP has created different designations to group together columns with similar types of packing and properties in the solid phase. SIELC's Legacy columns adhere to these strict requirements and properties so that you can easily replace older columns that are no longer available without having to significantly modify your method or SOPs.

Select options
Application Analytes:
Acetaminophen (Paracetamol)
Aspirin
Benzoic Acid
Caffeine

Application Detection:
UV Detection

USP Methods for the Analysis of Aspirin (Acetylsalicylic acid (ASA)) Using Legacy L1 Column

2012-06-21

 

Application Notes: Aspirin is one of the oldest analgesics. While it is one of the oldests analgesics, it is still widely used today, and is still one of the most common drugs. According to the USP methods, aspirin contains not less than 99.5% and no more than 100.5 percent of aspirin calculate on a dried basis. The USP HPLC method for the separation of aspirin was developed on Legacy L1 column according to the US Pharmacopeia methodology. L1 classification is assigned to reversed-phase HPLC column containing C18 ligand. Support for the material is spherical silica gel with particles size 3-10 um and pore size of 100-120A. Resolution between critical pairs corresponds to rules and specifications of USP.

Application Columns: Legacy L1 C18 HPLC column

Application compounds: Aspirin and salicylic acid

Mobile phase: 20 mM AmFm pH 3.0/MeCN- 75/25

Detection technique: UV

Reference: USP35: NF30

Condition

Column Legacy L1, 4.6×300 mm, 5 µm, 100A
Mobile Phase MeCN – 25%
Buffer AmFm pH 3.0 20 mM –  75%
Flow Rate 1.0 ml/min
Detection UV, 250 nm

 

Description

Class of Compounds
Drug, Acid, Hydrophobic, Ionizable
Analyzing Compounds Aspirin (Acetylsalicylic acid (ASA))

 

SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.
SIELC Legacy L1 HPLC column

Legacy L1

SIELC’s family of Legacy columns is based on United States Pharmacopeia’s (USP) published chromatographic methods and procedures. A plethora of brands have columns used in USP reference standards and methods, and USP has created different designations to group together columns with similar types of packing and properties in the solid phase. SIELC's Legacy columns adhere to these strict requirements and properties so that you can easily replace older columns that are no longer available without having to significantly modify your method or SOPs.

Select options
Application Analytes:
Acetylsalicylic Acid
Aspirin

Application Detection:
UV Detection

HPLC Separation of Components of Excedrin (Benzoic acid, Acetaminophen, Caffeine, Aspirin)

2009-07-16

Excedrin is over-the-counter pain reliever containing acetaminophen, caffeine and aspirin as active ingredients of this drug composition. Acetaminophen (paracetamol) is used as analgesic and pain reliever. It is a neutral compound with low hydrophobicity. Aspirin or acetylsalicylic acid is used as analgesic and anti-inflammatory component of many OTC compositions. It is weakly acidic and slightly hydrophobic compound. Caffeine is xanthine alkaloid which is psychoactive stimulant drug. All four compounds are separated on mixed-mode Primesep 100 HPLC column with acetonitrile/water/TFA mobile phase. In this HPLC application compounds are retained by reversed phase mechanism. This HPLC method is short and robust.

Condition

Column Primesep 100, 3.2×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O
Buffer TFA
Flow Rate 0.5 ml/min
Detection UV, 210 nm

 

Description

Class of Compounds
Acid, Hydrophilic, Ionizable
Analyzing Compounds Benzoic acid, Acetaminophen, Caffeine, Aspirin

 

SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Primesep 100

The Primesep family of mixed-mode columns offer a wide variety of stationary phases with an unprecedented selectivity in the separation of a broad array of chemical compounds and in multiple applications. Corresponding Primesep guard columns are available with all stationary phases and do not require holders. SIELC offers a method development service which is available for all customers. Ask about our special custom LC-phases tailored for specific separations.

Select options
Application Analytes:
Acetylsalicylic Acid
Aspirin
Benzoic Acid
Caffeine

Application Detection:
UV Detection
ELSD/MS Detection