Pantoprazole

Pantoprazole structural formula

CAS Number102625-70-7
Molecular FormulaC16H15F2N3O4S
Molecular Weight383.370
InChI KeyIQPSEEYGBUAQFF-UHFFFAOYSA-N
LogP1.56
Synonyms
  • Pantoprazole
  • 5-(Difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methanesulfinyl]-1H-benzimidazole
  • 1H-Benzimidazole, 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-
  • 102625-70-7
  • 1H-Benzimidazole, 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-
  • Pantoprazol
  • Pantoprazolum
  • UNII-D8TST4O562
  • Controloc Control
  • Pantecta Control
  • Pantoloc Control
  • Pantozol Control
  • Somac Control
  • apo-Pantoprazole
  • 6-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methane]sulfinyl}-1H-1,3-benzodiazole
  • Pantoloc
  • Pantoprazole Sodium Hydrate
  • Pantoprazole sodium
  • Pantozol
  • Protonix
  • Protonix I.V.

Applications:

Determination Pantoprazole on Obelisc R Column

2021-02-11

Separation type: Liquid Chromatography Ion Exclusion

HPLC.cloud View on hplc.cloud



High Performance Liquid Chromatography (HPLC) Method of Pantoprazole. Pantoprazole, a drug from the proton pump inhibitors (PPIs) group, is widely used for treatment of gastroesophageal disease and peptic ulcer. It can be retained on an Obelisc R column, which has both positive and negative ion-pairs embedded in the stationary phase, allowing for the fine tuning and separation of a wide range of compounds with different ionic properties. Pantoprazole can be determined isocratically using a simple MS-compatible mobile phase of acetonitrile (ACN) and water with Ammonium Acetate (AmAc) buffer and detected by UV at 290nm, ELSD, CAD or LC/MS.

 

Condition

Column Obelisc R, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeCN -35%
Buffer Ammonium Acetate  pH 5.5 - 10 mM
Flow Rate 1.0 ml/min
Detection UV 290 nm
 

Description

Class of Compounds  Drug
Analyzing Compounds Pantoprazole
 
Application Analytes:
Pantoprazole
Pantoprazole sodium

HPLC Method for Analysis of Pantoprazole Sodium in Tablets on Newcrom R1

2018-06-08
Pantoprazole Sodium in Tablets  

Condition

Column Newcrom R1  4.6x100 mm, 5 µm, 100A
Mobile Phase MeCN/H2O - 25/75%
Buffer TEAPh - 10 mM
Flow Rate 1.0ml/min
Detection UV, 290 nm
 

Description

Class of Compounds Drug, Proton-pump inhibitor, Hydrophobic, Neutral
Analyzing Compounds Pantoprazole
 
Application Analytes:
Pantoprazole
Pantoprazole sodium