HPLC Separation of Sodium, Potassium Ions and Tetramethylammonium Chloride on Newcrom AH Column

HPLC Method for Analysis of Tetramethylammonium, Sodium, Potassium on Newcrom AH by SIELC Technologies


Tetramethylammonium chloride is a quaternary ammonium salt used widely as a reagent in industrial applications.  It can be separated from sodium and potassium chlorides on a mixed-mode Newcrom AH column with a simple isocratic MS-compatible mobile phase of water, acetonitrile (ACN) and ammonium formate (AmFm) buffer.

ColumnNewcrom AH, 4.6 x 150 mm, 5 µm, 100 A
Mobile PhaseMeCN/H2O – 50/50%
BufferAmFm pH 3.0- 10 mM
Flow Rate1.0 ml/min
DetectionCAD (Corona) MS- compatible mobile phase
Class of CompoundsHydrophilic, Metal, Ion, Quaternary ammonium salt
Analyzing CompoundsTetramethylammonium, Sodium, Potassium

Application Column

Newcrom AH

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A

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Application Analytes:
Potassium
Sodium
Tetramethylammonium
Application Detection:
CAD Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.