HPLC Chiral Separation of 1-(2-Methylphenyl)-1-pyridin-4-ylmethanamine on Cyralis CM Column

HPLC Method for Analysis of 1-(2-Methylphenyl)-1-pyridin-4-ylmethanamine dihydrochloride on Cyralis CM Column by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of 1-(2-Methylphenyl)-1-pyridin-4-ylmethanamine dihydrochloride.

1-(2-Methylphenyl)-1-pyridin-4-ylmethanamine has the chemical formula C13H14N2.

This application describes a normal-phase chiral HPLC method for the separation of 1-(2-Methylphenyl)-1-pyridin-4-ylmethanamine dihydrochloride enantiomers using SIELC’s Cyralis CM chiral column. Cyralis CM is a cellulose-based chiral stationary phase (CSP) designed for enantiomeric separations, optical purity testing, chiral impurity analysis, and stereoisomer characterization in pharmaceutical, chemical, agrochemical, and fine chemical applications.

1-(2-Methylphenyl)-1-pyridin-4-ylmethanamine dihydrochloride can be retained and analyzed using the Cyralis CM stationary phase column. The analysis utilizes an isocratic method with a mobile phase consisting of Hexane, Ethanol, and DEA. Detection is performed using UV.

Condition

ColumnCyralis CM, 4.6 x 100 mm, 5 µm, 100 A, dual ended
Mobile PhaseHexane/Ethanol/DEA – 70/29/1%
Flow Rate1.0 mL/min
DetectionUV 250 nm
Resolution3.54

Description

Class of CompoundsChemical
Analyzing Compounds1-(2-Methylphenyl)-1-pyridin-4-ylmethanamine dihydrochloride

Application Column

Cyralis CM

Column Diameter: 4.6 mm
Column Length: 100 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
1-(2-Methylphenyl)-1-pyridin-4-ylmethanamine dihydrochloride
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.