Thiabendazole

Thiabendazole structural formula

CAS Number148-79-8
Molecular FormulaC10H7N3S
Molecular Weight201.250
InChI KeyWJCNZQLZVWNLKY-UHFFFAOYSA-N
LogP2.47
Synonyms
  • Thiabendazole
  • 2-(1,3-Thiazol-4-yl)-1H-benzimidazole
  • 1H-Benzimidazole, 2-(4-thiazolyl)-
  • 148-79-8
  • TB
  • 1H-Benzimidazole, 2-(4-thiazolyl)-
  • 2-(1,3-Thiazol-4-yl)-1H-benzimidazole
  • 2-(4-Thiazolyl)-1H-benzimidazole
  • 2-(4-Thiazolyl)-1H-benzoimidazole
  • 2-(4'-Thiazolyl)benzimidazole
  • 2-(4-THIAZOLYL)BENZIMIDAZOLE
  • 2-(4'-Thiazoyl)benzimidazole
  • 2-(4-Triazolyl)benzimidazole
  • 4-(1H-Benzimidazol-2-yl)thiazole
  • 5-(4-Thiazolyl)benzimidazole
  • Amolden HS
  • Benzimidazole, 2-(4-thiazolyl)-
  • BENZIMIDAZOLE[1H], 2-(4-THIAZOLYL)-
  • Bovizole
  • Chemviron TK 100
  • Cropasal
  • Drawipas
  • Eprofil
  • Equizole
  • Hokustar HP
  • Irgaguard F 3000
  • Lombristop
  • Marukacide M 101
  • Mertect
  • Mertect 160
  • Mertect 340F
  • Mertect LSP
  • Metasol TK 100
  • Metasol TK 25
  • Metasol TK 25AD
  • Metasol TK 50AD
  • Mintesol
  • Mintezol
  • Minzolum
  • Nemapan
  • NSC 525040
  • NSC 90507
  • Omnizole
  • Ormogal
  • Pitrizet
  • Polival
  • Sanaizol 100
  • Sanaizol TBZ-FL 25
  • Sistesan
  • Storite
  • Syntol M 100
  • Tebuzate
  • Tecto B
  • Thiaben
  • Thiabendazol
  • Thiabendole
  • Thiabenzole
  • Thibendole
  • Thibenzol
  • Thibenzole
  • Thibenzole 200
  • Tiabenda
  • tiabendazol
  • Tiabendazole
  • Top Form Wormer
  • Triasox
  • APL-luster
  • 4-(2-Benzimidazolyl)thiazole
  • Biogard
  • Bioguard
  • BRN 0611403
  • Captan T
  • Caswell No. 849A
  • EINECS 205-725-8
  • EPA Pesticide Chemical Code 060101
  • Helmindrax octelmin
  • Metasol TK-100
  • Mycozol
  • RTU Flowable Fungicide
  • Syntol M100
  • Tecto RPH
  • Thiabendazolum
  • 2-Thiazole-4-ylbenzimidazole
  • 2-(1,3-Thiazol-4-yl)benzimidazole
  • Thibenzole ATT
  • Mintezole
  • Tiabendazolum
  • UNII-N1Q45E87DT
  • 2-(thiazol-4-yl)benzimidazole
  • 1135441-27-8
  • 123242-33-1
  • 145316-67-2
  • 8018-04-0
  • 8027-10-9
  • 8028-27-1
  • 94977-06-7
  • 98002-42-7

Applications:

HPLC Method for Analysis of Thiabendazole on Primesep 100 Column

August 12, 2024

High Performance Liquid Chromatography (HPLC) Method for Analysis of Thiabendazole on Primesep 100 by SIELC Technologies

Separation type: Liquid Chromatography Mixed-mode SIELC Technologies

HPLC Method for Analysis of Thiabendazole on Primesep 100 Column


 High Performance Liquid Chromatography (HPLC) Method for Analysis of Thiabendazole

Thiabendazole is an anthelmintic and antifungal medication used to treat various parasitic worm infestations and fungal infections. It works by interfering with the energy metabolism of the parasites, effectively killing them. The drug is used in both humans and animals and can be administered orally or topically, depending on the condition being treated.

In humans, thiabendazole is commonly used to treat infections like strongyloidiasis (caused by the parasite Strongyloides stercoralis), trichinosis, and other helminthic infections. It is also sometimes used as a fungicide in agriculture to control mold, rot, and other fungal diseases in crops and fruits.

While effective, thiabendazole can cause side effects such as nausea, dizziness, and abdominal pain. It is typically prescribed when the benefits outweigh the potential risks, and the specific use and dosage depend on the patient’s condition and overall health.

Thiabendazole can be retained, separated and analyzed using a Primesep 100 mixed-mode stationary phase column. The analysis employs a gradient method with a simple mobile phase comprising water, acetonitrile (MeCN), and sulfuric acid as a buffer. This method allows for detection using UV 300 nm.

You can find detailed UV spectra of Thiabendazole and information about its various lambda maxima by visiting the following link.

ColumnPrimesep 100, 4.6 x 150 mm, 5 µm, 100 A
Mobile PhaseMeCN – 60%
BufferH2SO4 – 0.15%
Flow Rate1.0 ml/min
DetectionUV 300 nm
Limit of Detection10 ppb
* LOD was determined for this combination of instrument, method, and analyte, and it can vary from one laboratory to another even when the same general type of analysis is being performed.

Class of Compounds
Herbicide
Analyzing CompoundsThiabendazole

Application Column

Primesep 100

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A

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Application Analytes:
Thiabendazole

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Analysis of Pesticides: Thiamphenicol, Aniline, Simazine, Alachlor, Thiabendazole, Diazinon, Trifluralin on Primesep B2 Column

July 11, 2017

 

Condition 

Column Primesep B2, 3.2×100 mm, 5 µm, 100A
Mobile Phase Gradient MeCN – 35-85%, 6 min , 4 min hold
Buffer Gradient H2SO4 – 0.05- 0.15%, 6 min, 4 min hold
Flow Rate 0.6 ml/min
Detection UV, 230 nm

 

Description

Class of Compounds
Drug, Acid, Hydrophilic, Ionizable, Vitamin, Supplements
Analyzing Compounds Thiamphenicol, Aniline, Simazine, Alachlor, Thiabendazole, Diazinon, Trifluralin

 

Application Column

Primesep B2

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

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Application Analytes:
Alachlor
Aniline
Diazinon
Simazine
Thiabendazole
Thiamphenicol
Trifluralin
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Thiabendazole on Mixed-Mode HPLC Columns

September 9, 2015

Separation type: Liquid Chromatography Mixed-mode




 




 
High Performance Liquid Chromatography (HPLC) Method for Analysis of Thiabendazole.

Thiabendazole (TBZ) or tiabendazole is both a fungicide and parasiticide which goes by the trade names Mintezol and Tresaderm. As a fungicide, it controls mold and blight and as a parasiticide it can control various types of worms. According to the EURL-SRM (European Union Reference Laboratory – Single Residue Methods) TBZ is considered difficult to analyze by traditional multiresidue methods. We separated and analyzed TBZ using two mixed-mode columns with different modes of separation. Obelisc R has a long hydrophobic chain and multiple ion-pairing groups, and Primesep 100 contains acidic ion-pairing groups. Method is LC/MS compatible and can be use on many different pesticides.

 

Condition 1

Column Obelisc R, 2.1×150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN – 25-70%, 15 min
Buffer Gradient AmAc pH 3.0- 30-60 mM, 15 min
Flow Rate 0.4 ml/min
Detection UV, 270 nm

 

Condition 2

Column Obelisc R, 2.1×150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN – 10-70%, 15 min
Buffer Gradient AmAc pH 3.0- 20-60 mM, 15 min
Flow Rate 0.4 ml/min
Detection UV, 270 nm

 

Condition 3

Column Primesep 100, 2.1×150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN – 10-70%, 15 min
Buffer Gradient AmAc pH 3.0- 20-60 mM, 15 min
Flow Rate 0.4 ml/min
Detection UV, 270 nm

 

Description

Class of Compounds
 Insecticide, Herbicide, Fungicide,  Hydrophobic, Ionizable
Analyzing Compounds Thiabendazole

 

Application Column

Obelisc R

SIELC has developed the Obelisc™ columns, which are mixed-mode and utilize Liquid Separation Cell technology (LiSC™). These cost-effective columns are the first of their kind to be commercially available and can replace multiple HPLC columns, including reversed-phase (RP), AQ-type reversed-phase, polar-embedded group RP columns, normal-phase, cation-exchange, anion-exchange, ion-exclusion, and HILIC (Hydrophilic Interaction Liquid Chromatography) columns. By controlling just three orthogonal method parameters - buffer concentration, buffer pH, and organic modifier concentration - users can adjust the column properties with pinpoint precision to separate complex mixtures.

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Primesep 100

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Thiabendazole

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Analysis of Pesticides: Thiamphenicol, Aniline, Simazine, Alachlor, Thiabendazole, Diazinon, Trifluralin on Primesep 100 Column

June 11, 2014

Condition 

Column Primesep 100, 3.2×100 mm, 5 µm, 100A
Mobile Phase Gradient MeCN – 35-85%, 6 min , 4 min hold
Buffer Gradient H2SO4 – 0.05- 0.15%, 6 min, 4 min hold
Flow Rate 0.6 ml/min
Detection UV, 230 nm

 

Description

Class of Compounds
Drug, Acid, Hydrophilic, Ionizable, Vitamin, Supplements
Analyzing Compounds Thiamphenicol, Aniline, Simazine, Alachlor, Thiabendazole, Diazinon, Trifluralin

 

Application Column

Primesep 100

Column Diameter: 3.2 mm
Column Length: 100 mm
Particle Size: 5 µm
Pore Size: 100 A

Add to cart
Application Analytes:
(2H7)Aniline
Alachlor
Diazinon
Simazine
Thiabendazole
Thiamphenicol
Trifluralin
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Bendazoles on Primesep P Column

August 22, 2008

Eight bendazoles are separated on Primesep P HPLC column by combination of reverse phase and ion-exchange mechanisms. Primesep P column can be used when mixed-mode mechanisms, including pi-pi interactions, can benefit separation. HPLC column and method is compatible with UV detection technique.

Application Column

Primesep P

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

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Application Analytes:
2-Aminosulphone Albendazole Metabolite
5-Hydroxy Thiabendazole
Albendazole
Cambendazole
Carbendazim
Fenbendazole
Mebendazole
Oxfendazole
Thiabendazole

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.