Saccharin

Saccharin structural formula

CAS Number81-07-2
Molecular FormulaC7H5NO3S
Molecular Weight183.180
InChI KeyCVHZOJJKTDOEJC-UHFFFAOYSA-N
LogP0.91
Synonyms
  • Saccharin
  • 1H-1lambda6,2-Benzothiazole-1,1,3(2H)-trione
  • 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide
  • 81-07-2
  • 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide
  • 1,1-Dioxo-1,2-dihydro-1lambda6-benzo[d]isothiazol-3-one
  • [1,2-benzisothiazol-3(2H)-one, 1,1-dioxide]
  • 1,1-dioxido de 1,2-bencisotiazol-3(2H)-ona
  • 1,1-Dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazole
  • 1,1-Dioxo-1,2-benzisothiazol-3(2H)-one
  • 1,1-Dioxyde de 1,2-benzisothiazol-3(2H)-one
  • 1,1-dioxyde de 1,2-benzisothiazole-3(2H)-one
  • 1,2-Benzisothiazol-3(2H)-on-1,1-dioxid
  • 1,2-benzisothiazol-3(2H)-one 1,1-dioxide
  • 1,2-Benzisothiazolin-3-one, 1,1-dioxide
  • 1,2-Benzothiazol-3(2H)-one 1,1-dioxide
  • 1,2-Dihydro-2-ketobenzisosulfonazole
  • 2,3-Dihydro-1,2-benzisothiazol-3-one-1,1-dioxide
  • 2,3-DIHYDRO-1,2-BENZOISOTHIAZOL-3-ONE 1,1-DIOXIDE
  • 2,3-Dihydro-3-oxobenzisosulfonazole
  • 3-Benzisothiazolinone 1,1-dioxide
  • 3-Hydroxybenzisothiazole-S,S-dioxide
  • 550 Saccharine
  • Anhydro-o-sulfaminebenzoic acid
  • Benzoic sulfimide
  • Benzoic sulphinide
  • Benzosulfimide
  • Benzosulfinide
  • Garantose
  • Gluside
  • NSC 5349
  • o-Benzoic acid sulfimide
  • o-Benzoic sulfimide
  • o-Benzosulfimide
  • o-Benzoyl sulfimide
  • o-Sulfobenzimide
  • o-Sulfobenzoic acid imide
  • Saccharimide
  • Saccharin acid
  • Saccharin insoluble
  • Saccharine
  • Saccharinol
  • Saccharinose
  • Saccharol
  • Benzosulfimide, O-
  • EINECS 201-321-0
  • RCRA waste number U202
  • Saccharina
  • Sulfobenzimide, O-
  • NSC 5731
  • UNII-FST467XS7D
  • 1, 2-Benzisothiazol-3(2H)-one, 1,1-dioxide
  • 1, 2-Benzisothiazolin-3-one 1,1-dioxide
  • 1, 2-Dihydro-2-ketobenzisosulfonazole
  • 1,1-Diox-1,2-benzisothiazol-3-one
  • 1,1-Dioxide-1,2-benzisothiazol-3(2H)-one
  • 1,1-Dioxide-1,2-benzisothiazolin-3-one
  • 1,1-Dioxo-1,2-dihydro-1lambda*6*-benzo[D]isothiazol-3-one
  • 1,1-Dioxo-1,2-dihydro-benzo[d]isothiazol-3-one
  • 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide
  • 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide, 9CI
  • 1,2-Benzisothiazolin-3-one 1,1-dioxide
  • 1,2-Benzisothiazoline-3-one 1,1-dioxide
  • 1,2-Dihydro-2-ketobenzisosulphonazole
  • 2, 3-Dihydro-3-oxobenzisosulfonazole
  • 2,3-Dihydro-1,2-benzoisothiazol-3-one-1,1-dioxide
  • 2,3-Dihydro-3-oxo-Benzisosulfonazole
  • 2,3-Dihydro-3-oxobenzisosulphonazole
  • 2,3-Dihydroxy-1,2-benzisothiazol-3-one-1,1-dioxide
  • 2,3-dihydro-1λ⁶,2-benzothiazole-1,1,3-trione
  • 2-Sulfobenzoic acid imide
  • 2-Sulfobenzoicimide
  • 2-Sulphobenzoic imide
  • 3-Benzisothiazolinone 1, 1-dioxide
  • 3-Benzisothiazolinone 1,1-dioxide
  • 3-Hydroxybenzisothiazole S,S-dioxide
  • Benzo-2-sulfiide
  • Benzo-2-sulphimide
  • Benzo-sulphinide
  • Benzoic acid sulfimide
  • Benzoic sulfimide
  • Benzoic sulphimide
  • Benzosulphimide
  • Benzoylsulfonic Imide
  • E954
  • Glucid
  • Glycophenol
  • Hermesetas
  • Insoluble saccharin
  • Kandiset
  • LSA
  • Neosaccharin
  • O-Benzoic sulphimide
  • O-Benzosulphimide
  • O-Benzoyl sulphimide
  • O-Benzoylsulfimide
  • O-Sulfobenzoic imide
  • Sacarina
  • Saccharin (JP15/NF)
  • Saccharin [usan]
  • Saccharin, insoluble
  • Sacharin
  • Stilalgin
  • Sucre edulcor
  • Sucrette
  • Sweeta
  • Syncal
  • Zaharina
  • 126987-83-5
  • 474-91-9
  • 61255-27-4
  • 890126-34-8

Applications:

Uv-Vis Spectrum of Saccharin

February 3, 2026
Access the UV-Vis Spectrum SIELC Library

If you are looking for optimized HPLC method to analyze Saccharin check our HPLC Applications library

For optimal results in HPLC analysis, it is recommended to measure absorbance at a wavelength that matches the absorption maximum of the compound(s) being analyzed. The UV spectrum shown can assist in selecting an appropriate wavelength for your analysis. Please note that certain mobile phases and buffers may block wavelengths below 230 nm, rendering absorbance measurement at these wavelengths ineffective. If detection below 230 nm is required, it is recommended to use acetonitrile and water as low UV-transparent mobile phases, with phosphoric acid and its salts, sulfuric acid, and TFA as buffers.
For some compounds, the UV-Vis Spectrum is affected by the pH of the mobile phase. The spectra presented here are measured with an acidic mobile phase that has a pH of 3 or lower.

 

Application Analytes:
Saccharin
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Saccharin and Sorbitol

October 14, 2010


Sorbitol and saccharin are two sugar substitutes used in food and drinks. Separation of sorbitol and saccharin was achieved on a Primesep N HILIC column using acetonitrile/water with ammonium formate. Compounds were monitored by combination of UV and ELSD. Method is compatible with LC/MS detection.

Application Column

Primesep N

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Saccharin
Sorbitol
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Alginic Acid and Related Products

August 22, 2008

Alginate is used in various pharmaceutical preparations. Chemically, it is a linear copolymer with homopolymeric blocks of (1-4)-linked ?-D-mannuronate (M) and its C-5 epimer ?-L-guluronate (G) residues, respectively, covalently linked together in different sequences or blocks. Alginic acid can be separated from benzoate, citric acid and saccharin by mixed-mode chromatography on Primesep C HPLC column. This method can be used to quantitate alginic acid, citric acid or saccharin in complex mixtures. Various detection technique can be used (UV, ELSD, LC/MS), based on mobile phase selection.

Condition
Column Primesep C, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O
Buffer Na2HPO4
Flow Rate 0.25 ml/min
Detection UV, 210 nm

 

Description
Class of Compounds
 Acid, Hydrophilic, Ionizable
Analyzing Compounds Alginic acid, Citric acid, Benzoic acid, Saccharin

 

Application Column

Primesep C

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Alginic Acid
Benzoic Acid
Citric Acid
Saccharin
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.