Saccharin

CAS Number	81-07-2
Molecular Formula	C7H5NO3S
Molecular Weight	183.180
InChI Key	CVHZOJJKTDOEJC-UHFFFAOYSA-N
LogP	0.91
Synonyms	Saccharin 1H-1lambda⁶,2-Benzothiazole-1,1,3(2H)-trione 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide 81-07-2 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide 1,1-Dioxo-1,2-dihydro-1lambda6-benzo[d]isothiazol-3-one [1,2-benzisothiazol-3(2H)-one, 1,1-dioxide] 1,1-dioxido de 1,2-bencisotiazol-3(2H)-ona 1,1-Dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazole 1,1-Dioxo-1,2-benzisothiazol-3(2H)-one 1,1-Dioxyde de 1,2-benzisothiazol-3(2H)-one 1,1-dioxyde de 1,2-benzisothiazole-3(2H)-one 1,2-Benzisothiazol-3(2H)-on-1,1-dioxid 1,2-benzisothiazol-3(2H)-one 1,1-dioxide 1,2-Benzisothiazolin-3-one, 1,1-dioxide 1,2-Benzothiazol-3(2H)-one 1,1-dioxide 1,2-Dihydro-2-ketobenzisosulfonazole 2,3-Dihydro-1,2-benzisothiazol-3-one-1,1-dioxide 2,3-DIHYDRO-1,2-BENZOISOTHIAZOL-3-ONE 1,1-DIOXIDE 2,3-Dihydro-3-oxobenzisosulfonazole 3-Benzisothiazolinone 1,1-dioxide 3-Hydroxybenzisothiazole-S,S-dioxide 550 Saccharine Anhydro-o-sulfaminebenzoic acid Benzoic sulfimide Benzoic sulphinide Benzosulfimide Benzosulfinide Garantose Gluside NSC 5349 o-Benzoic acid sulfimide o-Benzoic sulfimide o-Benzosulfimide o-Benzoyl sulfimide o-Sulfobenzimide o-Sulfobenzoic acid imide Saccharimide Saccharin acid Saccharin insoluble Saccharine Saccharinol Saccharinose Saccharol Benzosulfimide, O- EINECS 201-321-0 RCRA waste number U202 Saccharina Sulfobenzimide, O- NSC 5731 UNII-FST467XS7D 1, 2-Benzisothiazol-3(2H)-one, 1,1-dioxide 1, 2-Benzisothiazolin-3-one 1,1-dioxide 1, 2-Dihydro-2-ketobenzisosulfonazole 1,1-Diox-1,2-benzisothiazol-3-one 1,1-Dioxide-1,2-benzisothiazol-3(2H)-one 1,1-Dioxide-1,2-benzisothiazolin-3-one 1,1-Dioxo-1,2-dihydro-1lambda6-benzo[D]isothiazol-3-one 1,1-Dioxo-1,2-dihydro-benzo[d]isothiazol-3-one 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide, 9CI 1,2-Benzisothiazolin-3-one 1,1-dioxide 1,2-Benzisothiazoline-3-one 1,1-dioxide 1,2-Dihydro-2-ketobenzisosulphonazole 2, 3-Dihydro-3-oxobenzisosulfonazole 2,3-Dihydro-1,2-benzoisothiazol-3-one-1,1-dioxide 2,3-Dihydro-3-oxo-Benzisosulfonazole 2,3-Dihydro-3-oxobenzisosulphonazole 2,3-Dihydroxy-1,2-benzisothiazol-3-one-1,1-dioxide 2,3-dihydro-1λ⁶,2-benzothiazole-1,1,3-trione 2-Sulfobenzoic acid imide 2-Sulfobenzoicimide 2-Sulphobenzoic imide 3-Benzisothiazolinone 1, 1-dioxide 3-Benzisothiazolinone 1,1-dioxide 3-Hydroxybenzisothiazole S,S-dioxide Benzo-2-sulfiide Benzo-2-sulphimide Benzo-sulphinide Benzoic acid sulfimide Benzoic sulfimide Benzoic sulphimide Benzosulphimide Benzoylsulfonic Imide E954 Glucid Glycophenol Hermesetas Insoluble saccharin Kandiset LSA Neosaccharin O-Benzoic sulphimide O-Benzosulphimide O-Benzoyl sulphimide O-Benzoylsulfimide O-Sulfobenzoic imide Sacarina Saccharin (JP15/NF) Saccharin [usan] Saccharin, insoluble Sacharin Stilalgin Sucre edulcor Sucrette Sweeta Syncal Zaharina 126987-83-5 474-91-9 61255-27-4 890126-34-8

Applications:

HPLC Separation of Saccharin and Sorbitol

October 14, 2010

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Sorbitol and saccharin are two sugar substitutes used in food and drinks. Separation of sorbitol and saccharin was achieved on a Primesep N HILIC column using acetonitrile/water with ammonium formate. Compounds were monitored by combination of UV and ELSD. Method is compatible with LC/MS detection.

Application Column

Primesep N

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options

Saccharin
Sorbitol

UV Detection

SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Alginic Acid and Related Products

August 22, 2008

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Alginate is used in various pharmaceutical preparations. Chemically, it is a linear copolymer with homopolymeric blocks of (1-4)-linked ?-D-mannuronate (M) and its C-5 epimer ?-L-guluronate (G) residues, respectively, covalently linked together in different sequences or blocks. Alginic acid can be separated from benzoate, citric acid and saccharin by mixed-mode chromatography on Primesep C HPLC column. This method can be used to quantitate alginic acid, citric acid or saccharin in complex mixtures. Various detection technique can be used (UV, ELSD, LC/MS), based on mobile phase selection.