Nutrasweet

CAS Number	22839-47-0
Molecular Formula	C14H18N2O5
Molecular Weight	294.308
InChI Key	IAOZJIPTCAWIRG-QWRGUYRKSA-N
LogP	0.0904
Synonyms	Aspartame Methyl L-alpha-aspartyl-L-phenylalaninate L-Phenylalanine, L-alpha-aspartyl-, methyl ester 22839-47-0 L-Phenylalanine, L-α-aspartyl-, 2-methyl ester aspartam aspartamo Aspartylphenylalanine methyl ester Canderel Dipeptide sweetener L-Aspartame L-Aspartyl-L-3-phenylalanine methyl ester L-Aspartyl-L-phenylalanine methyl ester L-Aspartyl-L-phenylalanyl methyl ester L-Phenylalanine, N-L-α-aspartyl-, 1-methyl ester L-α-Aspartyl-L-phenylalanine methyl ester Methyl aspartylphenylalanate NutraSweet Pal Sweet Palsweet Diet PHENYLALANINE (L), N-L-α-ASPARTYL-O-METHYL- Succinamic acid, 3-amino-N-(α-carboxyphenethyl)-, N-methyl ester, stereoisomer α-Aspartame α-L-Aspartyl-L-phenylalanine methyl ester α-Sweet 3-Amino-N-(alpha-carboxyphenethyl)succinamic acid N-methyl ester, stereoisomer 3-Amino-N-(alpha-methoxycarbonylphenethyl) succinamic acid Aspartame, L,L-alpha- N-L-alpha-Aspartyl-L-phenylalanine 1-methyl ester EINECS 245-261-3 Methyl L-alpha-aspartyl-L-phenylalanate Methyl N-L-alpha-aspartyl-L-phenylalaninate Methyl L-aspartyl-L-phenylalanine 1-Methyl N-L-alpha-aspartyl-L-phenylalanine Tri-sweet Aspartamum UNII-Z0H242BBR1 (3S)-3-amino-3-{[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]carbamoyl}propanoic acid 1-methyl N-L-alpha-aspartyl-L-phenylalanate 3-Amino-N-(alpha-carboxyphenethyl)succinamic acid N-methyl ester 3-Amino-N-(alpha-methoxycarbonylphenethyl) succinamic acid Asp-phe-ome E 951 L-Aspartyl-L-phenylalanine methyl ester Sweet dipeptide 172964-81-7 53906-69-7 7421-84-3

Applications:

Bufferless Ion Separation (BLIS™) Chromatography of Aspartame: Organic Modifier Effect

January 30, 2005

View Application

An organic modifier effect of changing acetonitrile percentage the mobile phase is demonstrated on a Primesep C HPLC column in a bufferless ion (BLIS™) separation. With decreasing percent acetonitrile, the artificial sweetener, Aspartame, first deceases in retention time and then increases. The changing mobile phase composition changes the retention mechanism from hydrophobic and BLIS™interactions, to BLIS™ alone , to BLIS™ and HILIC (hydrophilic liquid chromatography) interactions. Aspartame is composed of the two amino acids, aspartic acid and phenylalanine as the ethyl ester. Mobile phases composed of water and acetonitrile (MeCN, ACN,) and ultraviolet (UV) detection was used.

Application Column

Primesep C

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options

Aspartame
Nutrasweet

UV Detection

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