2,6-Dihydroxybenzoic acid

CAS Number303-07-1
Molecular Formula C7H6O4
Molecular Weight154.12
InChI KeyAKEUNCKRJATALU-UHFFFAOYSA-N
LogP2.2
Synonyms
  • 2,6-DIHYDROXYBENZOIC ACID
  • 303-07-1
  • gamma-Resorcylic acid
  • 2,6-Resorcylic acid
  • 2-Carboxyresorcinol
  • Benzoic acid, 2,6-dihydroxy-
  • 6-Hydroxysalicylic acid
  • .gamma.-Resorcylic acid
  • UNII-RSA5G6VRPV
  • RSA5G6VRPV
  • EINECS 206-134-8
  • MFCD00002462
  • NSC 49172
  • 2,6-dihydroxy benzoic acid
  • 2,6-dihydroxy-benzoic acid
  • BRN 2209755
  • CHEBI:68465
  • AKEUNCKRJATALU-UHFFFAOYSA-N
  • Resorcinol-2-Carboxylic Acid
  • 2,6-Dihydroxybenzoic acid, 97%
  • gamma-Resorcylsaeure
  • 2,6-Dihydroxybenzoesaeure
  • 2,6-Dihydroxybenzoesaeure [IUPAC]
  • PubChem21431
  • ACMC-1CRQN
  • 2,6-Dihydroxylbenzoicacid
  • Benzoic acid,6-dihydroxy-
  • 2,6-Dihydroxybenzoate, VII
  • 4-10-00-01456 (Beilstein Handbook Reference)
  • gamma-Resorcylic acid (8CI)
  • KSC222G5P
  • SCHEMBL224031
  • CHEMBL454808
  • DTXSID1059785
  • BDBM92712
  • CTK1C2357
  • 2,6-Dihydroxybenzoic acid, 98%
  • ZINC388545
  • HY-Y0801
  • NSC49172
  • STR05041
  • ANW-26827
  • BBL011022
  • NSC-49172
  • s6031
  • SBB058835
  • STK802162
  • AKOS005622669
  • AC-7284
  • AS04461
  • MCULE-1114504762
  • RTR-036416
  • TRA0060740
  • AK-46623
  • BR-46623
  • LS-37058
  • SC-22419
  • SY005481
  • AB1008695
  • DB-030809
  • ST2409210
  • TR-036416
  • 2,6-Dihydroxybenzoic acid (ACD/Name 4.0)
  • AM20050237
  • CS-0015783
  • FT-0610667
  • R0011
  • ST50824440
  • C21298
  • M-3978
  • 303D071
  • AE-562/42007307
  • BENZOIC ACID,2,6-DIHYDROXY MFC7 H6 O4
  • Q-200213
  • Q4596804
  • Z1695729017
  • 2,6-Dihydroxybenzoic acid, Vetec(TM) reagent grade, 98%

Applications:

Uv-Vis Spectrum of 2,6-Dihydroxybenzoic

February 13, 2026
Access the UV-Vis Spectrum SIELC Library

If you are looking for optimized HPLC method to analyze 2,6-Dihydroxybenzoic acid check our HPLC Applications library

For optimal results in HPLC analysis, it is recommended to measure absorbance at a wavelength that matches the absorption maximum of the compound(s) being analyzed. The UV spectrum shown can assist in selecting an appropriate wavelength for your analysis. Please note that certain mobile phases and buffers may block wavelengths below 230 nm, rendering absorbance measurement at these wavelengths ineffective. If detection below 230 nm is required, it is recommended to use acetonitrile and water as low UV-transparent mobile phases, with phosphoric acid and its salts, sulfuric acid, and TFA as buffers.
For some compounds, the UV-Vis Spectrum is affected by the pH of the mobile phase. The spectra presented here are measured with an acidic mobile phase that has a pH of 3 or lower.

 

 

 

Application Analytes:
2,6-Dihydroxybenzoic acid
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Dihydroxybenzoic Acids on Newcrom B Column

April 24, 2020

HPLC Method for 2,3-Dihydroxybenzoic Acid, 2,4-Dihydroxybenzoic Acid, 2,5-Dihydroxybenzoic Acid, 3,4-Dihydroxybenzoic Acid, 3,5-Dihydroxybenzoic Acid, 2,6-Dihydroxybenzoic acid on Newcrom B by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of 2,3-Dihydroxybenzoic Acid, 2,4-Dihydroxybenzoic Acid, 2,5-Dihydroxybenzoic Acid, 3,4-Dihydroxybenzoic Acid, 3,5-Dihydroxybenzoic Acid, 2,6-Dihydroxybenzoic acid.

Dihydroxybenzoic acids are aromatic compounds consisting of a phenolic ring and a carboxylic acid. They all have the same chemical formula C7H6O4.

The six main compounds are structurally similar and are difficult to separate in reverse-phase HPLC. The can be separated by using a mixed-mode Newcrom B column with the mobile phase having either methanol (MeOH) or acetonitrile (ACN) as an organic modifier having different retention characteristics. Using the gradient of organic modifier, water and sulfuric acid (H2SO4) as buffer, dihydroxybenzoic acids can be separated and UV detected at 250nm.

You can find detailed UV spectra of 2,3-Dihydroxybenzoic Acid, 2,4-Dihydroxybenzoic Acid, 2,5-Dihydroxybenzoic Acid, 3,4-Dihydroxybenzoic Acid, 3,5-Dihydroxybenzoic Acid, 2,6-Dihydroxybenzoic acid and information about its various lambda maxima by visiting the following links for 3.4 DHBA, 3.5 DHBA, 2.4 DHBA, and 2.5 DHBA.

Condition
Column Newcrom B, 4.6 x 150 mm, 5 µm, 100 A, dual ended
Mobile Phase MeCN
Buffer H2SO4
Flow Rate 1.0 ml/min
Detection UV, 250 nm

 

Description
Class of Compounds
 Drug, Acid, Hydrophilic, Ionizable, Vitamin, Supplements
Analyzing Compounds 2,3-Dihydroxybenzoic Acid, 2,4-Dihydroxybenzoic Acid, 2,5-Dihydroxybenzoic Acid, 3,4-Dihydroxybenzoic Acid, 3,5-Dihydroxybenzoic Acid, 2,6-Dihydroxybenzoic acid

 

Application Column

Newcrom B

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
2,3-Dihydroxybenzoic Acid
2,4-Dihydroxybenzoic Acid
2,5-Dihydroxybenzoic Acid
2,6-Dihydroxybenzoic acid
3,4-Dihydroxybenzoic Acid
3,5-Dihydroxybenzoic Acid
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.