Vincristine sulfate

Vincristine sulfate structural formula

CAS Number2068-78-2
Molecular FormulaC46H58N4O14S
Molecular Weight923.040
InChI KeyAQTQHPDCURKLKT-JKDPCDLQSA-N
LogP3.08
Synonyms
  • Vincristine sulfate
  • Sulfuric acid--(2'beta)-22-oxovincaleukoblastine (1/1)
  • Vincaleukoblastine, 22-oxo-, (2'beta)-, sulfate (1:1)
  • 2068-78-2
  • Vincristine sulfate salt
  • Alkaloid extracted from Vinca rosea Linn
  • EINECS 218-190-0
  • Kyocristine
  • Leurocristine sulfate
  • Lilly 37231
  • Oncovin
  • Onkovin
  • VCR sulfate
  • Vincrex
  • Vincrisul
  • Vincasar PFS
  • Vincristine sulfate PFS
  • Vincristinsulfat
  • UNII-T5IRO3534A
  • Vincristine Sulfate Liposomes Injection
  • Marqibo

Applications:

Separation of Vincristine sulfate on Newcrom R1 HPLC column

May 16, 2018
Separation of Vincristine sulfate on Newcrom R1 HPLC column

Vincristine sulfate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Vincristine sulfate
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.