Promethazine hydrochloride

Promethazine hydrochloride structural formula

CAS Number58-33-3
Molecular FormulaC17H21ClN2S
Molecular Weight320.881
InChI KeyXXPDBLUZJRXNNZ-UHFFFAOYSA-N
LogP4.38
Synonyms
  • Promethazine hydrochloride
  • N,N-Dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine--hydrogen chloride (1/1)
  • 10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl-, hydrochloride (1:1)
  • 58-33-3
  • 10H-Phenothiazine-10-ethanamine, N,N,?-trimethyl-, monohydrochloride
  • 10-[2-(Dimethylamino)propyl]phenothiazine hydrochloride
  • 10H-Phenothiazine-10-ethanamine, N,N,?-trimethyl-, hydrochloride (1:1)
  • Diprasine
  • Diprazin
  • Duplamin
  • Fellozine
  • Fenazil
  • Fenergan
  • Genphen
  • Hiberna
  • Himazin
  • Kinetosin
  • Lergigan
  • Mepergan
  • N,N,?-Trimethyl-10H-phenothiazine-10-ethanamine monohydrochloride
  • NSC 231688
  • Phanergan D
  • Phencen
  • Phenergan
  • Phenergan VC
  • Phenothiazine, 10-[2-(dimethylamino)propyl]-, monohydrochloride
  • Pipolfen
  • Pipolphen
  • Plletia
  • Promasun
  • prometazina, clorhidrato
  • Promethazine chloride
  • Promethazine monohydrochloride
  • Promethazine, chlorhydrate
  • Promethazinhydrochlorid
  • Promethazinium chloride
  • Prothazine
  • Provigan
  • Pyrethia
  • Romergan
  • Romergan hydrochloride
  • N-(2'-Dimethylamino-2'-methyl)ethylphenothiazine hydrochloride
  • 10-(2-Dimethylaminopropyl)phenothiazine hydrochloride
  • 10-(2-(Dimethylamino)propyl)phenothiazine monohydrochloride
  • EINECS 200-375-2
  • Ganphen
  • Phenothiazine, 10-(2-(dimethylamino)-propyl)-, hydrochloride
  • Primine
  • Promantine
  • Promine
  • Allerfen
  • Eusedon Mono
  • Farganesse
  • Frinova
  • Goodnight
  • Hibechin
  • Histantil
  • PMS Promethazine
  • Proneurin
  • Soporil
  • Phenadoz
  • Mymethazine Fortis
  • Phenergan Fortis
  • Phenergan Plain
  • Prometh Fortis
  • Prometh Plain
  • Promethazine Plain
  • Promethiazin
  • UNII-R61ZEH7I1I
  • (+-)-10-(2-(Dimethylamino)propyl)phenothiazine monohydrochloride
  • 10-(2-Dimethylamino-1-propyl)phenothiazine hydrochloride
  • 10-(3-Dimethylaminoisopropyl)phenothiazine hydrochloride
  • N-(2'-dimethylamino-2'-methyl)ethylphenothiazine hydrochloride
  • N-(2-dimethylaminopropyl-1)phenothiazine hydrochloride
  • promethazine HCl
  • 16639-38-6
  • 88208-28-0

Applications:

Separation of Promethazine hydrochloride on Newcrom R1 HPLC column

February 16, 2018
Separation of Promethazine hydrochloride on Newcrom C18 HPLC column

Promethazine hydrochloride can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Promethazine hydrochloride
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.