L-Glutamic acid hydrochloride

L-Glutamic acid hydrochloride structural formula

CAS Number138-15-8
Molecular FormulaC5H10ClNO4
Molecular Weight183.590
InChI KeyRPAJSBKBKSSMLJ-DFWYDOINSA-N
LogP-2.51
Synonyms
  • L-Glutamic acid hydrochloride
  • L-Glutamic acid--hydrogen chloride (1/1)
  • L-Glutamic acid, hydrochloride (1:1)
  • 138-15-8
  • Acidalin
  • Acidogen
  • Acidoride
  • Acidothyn
  • Acidulin
  • Aciglumin
  • Acigluminum
  • alpha-Aminopentanedioic acid, hydrochloride, L-
  • 2-Aminopentanedioic acid hydrochloride
  • Antalka
  • EINECS 205-315-9
  • Flamithin
  • Flanithin
  • Gastuloric
  • Glusatin
  • Glutamic acid, L-, hydrochloride
  • Glutamic acid, hydrochloride, L-
  • Glutamic acid hydrogen chloride
  • L-Glutamic acid monohydrochloride
  • Glutamidin
  • Glutamidine
  • Glutan hcl
  • Glutan hydrochloride
  • Glutasin
  • Hydrionic
  • Hypochylin
  • Muriamic
  • NSC 9239
  • Pepsdol
  • Feracid
  • Glutan-HCl
  • Glutamic acid HCl
  • UNII-M0C2SP444T
  • 125685-10-1

Applications:

HPLC Method for Separation of Ibotenic Acid and Glutamic Acid on Primesep A Column

February 28, 2023

HPLC Method for Separation of Ibotenic Acid and Glutamic Acid on Primesep A by SIELC Technologies

Separation type: Liquid Chromatography Mixed-mode

HPLC Method for Separation of Ibotenic Acid and Glutamic Acid on Primesep A by SIELC Technologies
Method for Separation of Ibotenic Acid and Glutamic Acid on Primesep A by SIELC Technologies

Ibotenic acid is a physchoactive NDMA and metabotropic glutamate receptor agonist with neurotoxic properties. These structurally similar psychoactive drugs can be retained, separated, and analyzed on a mixed-mode Primesep A column with a mobile phase consisting of water, Acetonitrile (MeCN), and Phosphoric acid (H3PO4). This analytical method can be UV detected at 210 nm with high resolution and peak symmetry.

High Performance Liquid Chromatography (HPLC) Method for Analysis of  Ibotenic Acid and Glutamic Acid

Condition

ColumnPrimesep A, 4.6 x 150 mm, 5 µm, 100 A
Mobile PhaseMeCN/H2O – 5/95%
BufferH3PO4 – 0.1%
Flow Rate1.0 ml/min
DetectionUV 210 nm
Peak Retention Time3.22 min, 10.52 min

Description

Class of CompoundsAcid
Analyzing CompoundsIbotenic Acid, Glutamic Acid

Application Column

Primesep A

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A

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Application Analytes:
D-Glutamic acid
GLU (L-Glutamic acid)
Glutamic Acid
Ibotenic acid
L-Glutamic acid hydrochloride
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of L-Glutamic acid hydrochloride on Newcrom R1 HPLC column

February 16, 2018
Separation of L-Glutamic acid hydrochloride on Newcrom C18 HPLC column

L-Glutamic acid hydrochloride can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
L-Glutamic acid hydrochloride
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.