Terephthalic Acid

Terephthalic Acid structural formula

CAS Number100-21-0
Molecular FormulaC8H6O4
Molecular Weight166.133
InChI KeyKKEYFWRCBNTPAC-UHFFFAOYSA-N
LogP2.00
Synonyms
  • Terephthalic acid
  • Benzene-1,4-dicarboxylic acid
  • 1,4-Benzenedicarboxylic acid
  • 100-21-0
  • TPA
  • 1,4-Benzenedicarboxylic acid
  • 4-09-00-03301
  • 1,4-BENZENEDICARBOXYLIC ACID, PARA-PHTHALIC ACID
  • 1,4-Dicarboxybenzene
  • 4-Carboxybenzoic acid
  • Acide terephtalique
  • acido tereftalico
  • Amoco TA 33
  • NSC 36973
  • para-Phthalic acid
  • p-Benzenedicarboxylic acid
  • p-Carboxybenzoic acid
  • p-Dicarboxybenzene
  • p-Phthalic acid
  • PURIFIED TEREPHTHALIC ACID
  • TEREPHTHALSAEURE
  • Terephthalsaure
  • BRN 1909333
  • EINECS 202-830-0
  • Tephthol
  • Kyselina tereftalova
  • UNII-6S7NKZ40BQ
  • Benzene-p-dicarboxylate
  • Benzene-p-dicarboxylic acid
  • Kyselina terftalova
  • P-Phthelate
  • P-Phthelic acid
  • p-Benzenedicarboxylate
  • p-Phthalate
  • p-Phthalic acid
  • para-benzenedicarboxylic acid
  • 211863-90-0
  • 211863-92-2

Applications:

UV-Vis Spectrum of Terephthalic acid

August 27, 2024
UV-Vis Spectrum of Terephthalic acid. Absorption Maxima: 190 nm, 241 nm, 285nm.

For optimal results in HPLC analysis, it is recommended to measure absorbance at a wavelength that matches the absorption maximum of the compound(s) being analyzed. The UV spectrum shown can assist in selecting an appropriate wavelength for your analysis. Please note that certain mobile phases and buffers may block wavelengths below 230 nm, rendering absorbance measurement at these wavelengths ineffective. If detection below 230 nm is required, it is recommended to use acetonitrile and water as low UV-transparent mobile phases, with phosphoric acid and its salts, sulfuric acid, and TFA as buffers.
For some compounds, the UV-Vis Spectrum is affected by the pH of the mobile phase. The spectra presented here are measured with an acidic mobile phase that has a pH of 3 or lower.

Application Analytes:
Terephthalic Acid
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Phthalic Acids and Related Impurities

July 2, 2013

 

Phthalic acid, phthalic acid isomers, and related products present in the production of phthalic acid were separated on the Primesep D column, based on reversed-phase and in-exchange mechanisms. Neutral, hydrophobic compounds of the phthalic acid production are retained by a reversed-phase mechanism, and phthalic acid and other acidic compounds are retained by a combination of reversed-phase and anion-exchange mechanisms. Resolution and selectivity of this separation can be modified by varying the amount of acetonitrile, buffer concentrations, and buffer pH. This method can be used for monitoring the production cycle of phthalic acid and related impurities.

 

Condition

Column Primesep D, 4.6×150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN – 10-50%, 15 min
Buffer H2SO4 – 0.1%
Flow Rate 1.0 ml/min
Detection UV, 210 nm

 

Description

Class of Compounds
Acid, Hydrophilic, Ionizable
Analyzing Compounds Terephthalaldehyde, Phthalic acid, 4-Carboxybenzaldehyde, Benzoic acid, Terephthalic acid, p –Tolualdehyde, p-Toluic acid

 

Application Column

Primesep D

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
4-Carboxybenzaldehyde
Benzoic Acid
Phthalic Acid
Terephthalaldehyde
Terephthalic Acid
p-Tolualdehyde
p-Toluic Acid

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Phthalic Acids using Hydrogen Bonding

June 18, 2012

 

Phthalic acid, isophthalic acid and terephthalic acid are all isomers of each other. Being structurally similar, they can present difficulties to reverse-phase HPLC separation. Methods that require high organic concentrations in the mobile phase can cause dewetting in many reverse-phase columns. SHARC 1 column can be operated in anhydrous conditions and uses hydrogen bonding as the mechanism of separation. Here, phthalic acids were separated in pure acetonitrile (ACN), with the ability to adjust retention times by adding methanol (MeOH) to the mobile phase with formic acid and ammonium formate as buffer, making the method MS-compatible. Can also be UV detected at 270nm.

Condition

Column Sharc 1, 3.2×100 mm, 5 µm, 100A
Mobile Phase MeCN/MeOH
Buffer AmFm, Formic acid
Flow Rate 1.0 ml/min
Detection UV, 270 nm

 

Description

Class of Compounds
Drug, Acid, Hydrophilic, Ionizable, Vitamin, Supplements
Analyzing Compounds Phthalic acid, Terephthalic acid, Isophthalic acid

 

Application Column

SHARC 1

The SHARC™ family of innovative columns represents the first commercially available columns primarily utilizing separation based on hydrogen bonding. SHARC stands for Specific Hydrogen-bond Adsorption Resolution Column. Hydrogen bonding involves an interaction or attraction between a bound hydrogen atom and molecules containing electronegative atoms, such as oxygen, nitrogen, and fluorine.

Select options
Application Analytes:
Isophthalic acid
Phthalic Acid
Terephthalic Acid
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.