4-Carboxybenzaldehyde structural formula

CAS Number619-66-9
Molecular FormulaC8H6O3
Molecular Weight150.133
  • 4-Carboxybenzaldehyde
  • 4-Formylbenzoic acid
  • Benzoic acid, 4-formyl-
  • 619-66-9
  • Benzoic acid, 4-formyl-
  • 4-10-00-02752
  • 4-Carboxylbenzaldehyde
  • 4-Formylbenzoesaure
  • 4-formylbenzoic acid
  • Acide 4-formylbenzoique
  • acido 4-formilbenzoico
  • NSC 15797
  • p-Carboxybenzaldehyde
  • p-Formylbenzoic acid
  • Terephthalaldehydic acid
  • Terephthaldehydic acid
  • BRN 0471734
  • EINECS 210-607-4


Separation of Phthalic Acids and Related Impurities

July 2, 2013


Phthalic acid, phthalic acid isomers, and related products present in the production of phthalic acid were separated on the Primesep D column, based on reversed-phase and in-exchange mechanisms. Neutral, hydrophobic compounds of the phthalic acid production are retained by a reversed-phase mechanism, and phthalic acid and other acidic compounds are retained by a combination of reversed-phase and anion-exchange mechanisms. Resolution and selectivity of this separation can be modified by varying the amount of acetonitrile, buffer concentrations, and buffer pH. This method can be used for monitoring the production cycle of phthalic acid and related impurities.



Column Primesep D, 4.6×150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN – 10-50%, 15 min
Buffer H2SO4 – 0.1%
Flow Rate 1.0 ml/min
Detection UV, 210 nm



Class of Compounds
Acid, Hydrophilic, Ionizable
Analyzing Compounds Terephthalaldehyde, Phthalic acid, 4-Carboxybenzaldehyde, Benzoic acid, Terephthalic acid, p –Tolualdehyde, p-Toluic acid


Application Column

Primesep D

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Benzoic Acid
Phthalic Acid
Terephthalic Acid
p-Toluic Acid

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.