Triflic acid

CAS Number1493-13-6
Molecular FormulaCHF3O3S
Molecular Weight150.08
InChI KeyITMCEJHCFYSIIV-UHFFFAOYSA-N
LogP3.3
Synonyms
  • Trifluoromethanesulfonic acid
  • 1493-13-6
  • Triflic acid
  • Perfluoromethanesulfonic acid
  • Trifluoromethanesulphonic acid

Applications:

ELSD HPLC Method for Analysis of Triflic acid on Primesep B Column

June 16, 2025

HPLC Method for Triflic acid on Primesep B by SIELC Technologies


High Performance Liquid Chromatography (HPLC) Method for Analysis of Triflic acid

Triflic acid, also known as trifluoromethanesulfonic acid, is a superacid with the chemical formula:

CF₃SO₃H

Common Uses:

  1. Catalysis:
    • Acid-catalyzed reactions (e.g. Friedel–Crafts acylations)
    • Polymerizations
  2. Activation of substrates:
    • Converts alcohols into better leaving groups
    • Used in making triflate esters (–OTf groups), which are great leaving groups in substitution and cross-coupling reactions
  3. Superacid chemistry:
    • Used as a component of “Magic Acid” (FSO₃H + SbF₅)

Triflic acid can be retained and analyzed using the Primesep B mixed mode column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water, acetonitrile and ammonium formate. Detection is performed using ELSD.

ColumnPrimesep B, 4.6 x 150 mm, 5 µm, 100 A, dual ended
Mobile PhaseMeCN/H2O – 70/30%
BufferAmmonium Formate pH 3.0 – 40 mM
Flow Rate1.0 ml/min
DetectionELSD, the nebulizer and evaporator temperatures 40°C,
with a gas flow rate of 1.6 Standard Liters per Minute (SLM)
LOD200 ppb

*LOD was determined for this combination of instrument, method, and analyte, and it can vary from one laboratory to another even when the same general type of analysis is being performed.

Class of CompoundsAcid
Analyzing CompoundsTriflic acid

Application Column

Primesep B

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Triflic acid
Application Detection:
ELSD Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.