Sulfamethazine

Sulfamethazine structural formula

CAS Number57-68-1
Molecular FormulaC12H14N4O2S
Molecular Weight278.330
InChI KeyASWVTGNCAZCNNR-UHFFFAOYSA-N
LogP0.19
Synonyms
  • Sulfamethazine
  • 4-Amino-N-(4,6-dimethylpyrimidin-2-yl)benzene-1-sulfonamide
  • Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-
  • 57-68-1
  • 5-25-10-00250
  • Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-
  • 2-(4-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine
  • 2-(4-Aminobenzenesulfonylamino)-4,6-dimethylpyrimidine
  • 2-(p-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine
  • 2-Sulfanilamido-4,6-dimethylpyrimidine
  • 4,6-Dimethyl-2-sulfanilamidopyrimidine
  • 4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide
  • 4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide
  • Azolmetazin
  • Calfspan
  • Calfspan Tablets
  • Cremomethazine
  • DiazilSulfadine
  • Dimezathine
  • Dimidin R
  • Kelametazine
  • Mermeth
  • N-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide
  • N1-(4,6-Dimethyl-2-pyrimidinyl)sulfanilamide
  • N1-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide
  • Neasina
  • Neazina
  • NSC 67457
  • NSC 683529
  • Panazin
  • Pirmazin
  • S-Dimidine
  • Spanbolet
  • Sulfadimerazine
  • Sulfadimesin
  • Sulfadimesine
  • Sulfadimethyldiazine
  • Sulfadimethylpyrimidine
  • Sulfadimezin
  • Sulfadimezine
  • Sulfadimidin
  • sulfadimidina
  • Sulfadimidine
  • Sulfadine
  • SULFAMETHAZINE BASE
  • Sulfamethiazine
  • Sulfanilamide, N1-(4,6-dimethyl-2-pyrimidinyl)-
  • SulfaSURE SR Bolus
  • Sulfodimesin
  • Sulfodimezine
  • Sulka K Boluses
  • Sulphadimethylpyrimidine
  • Sulphadimidine
  • Sulphamethasine
  • Sulphamethazine
  • Sulphamezathine
  • Sulphamidine
  • Sulphodimezine
  • Superseptil
  • Superseptyl
  • Sustain III
  • Vertolan
  • Benzenesulfonamide, 4-amino-N-(2,6-dimethyl-4-pyrimidinyl)-
  • BRN 0261304
  • Dimidin-R
  • EINECS 200-346-4
  • Hava-Span
  • Intradine
  • NCI-C56600
  • Sulfadimezinum
  • Sulfa-Isodimerazine
  • Sulfanilamide, N(1)-(4,6-dimethyl-2-pyrimidinyl)-
  • Sulfanilamide, N(sup1)-(2,6-dimethyl-4-pyrimidinyl)-
  • Sulfanilamide, N(sup1)-(4,6-dimethyl-2-pyrimidinyl)-
  • N(sup 1)-(4,6-Dimethyl-2-pyrimidinyl)sulfanilamide
  • N(sup 1)-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide
  • (p-Aminobenzolsulfonyl)-2-amino-4,6-dimethylpyrimidin
  • Solfadimidina
  • Sulfadimidinum
  • UNII-48U51W007F
  • Sentry aq mardel biospheres maracyn plus
  • 2-Sulfanilamido-4,6-dimethylpyrimidine
  • 4-Amino-N-(4,6-dimethyl-pyrimidin-2-yl)-benzenesulfonamide
  • 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
  • 6-(4'-Aminobenzol-sulfonamido)-2,4-dimethylpyrimidin
  • N(1)-(4,6-Dimethyl-2-pyrimidinyl)sulfanilamide
  • N(1)-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide
  • N-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide
  • SMZ
  • Sulfametazina
  • Sulfametazyny
  • Sulfamezathine
  • sulfamethazone

Applications:

UV-Vis Spectrum of Sulfamethazine

July 19, 2024
UV-Vis Spectrum of Sulfamethazine. Absorption Maxima: 268 nm.

For optimal results in HPLC analysis, it is recommended to measure absorbance at a wavelength that matches the absorption maximum of the compound(s) being analyzed. The UV spectrum shown can assist in selecting an appropriate wavelength for your analysis. Please note that certain mobile phases and buffers may block wavelengths below 230 nm, rendering absorbance measurement at these wavelengths ineffective. If detection below 230 nm is required, it is recommended to use acetonitrile and water as low UV-transparent mobile phases, with phosphoric acid and its salts, sulfuric acid, and TFA as buffers.
For some compounds, the UV-Vis Spectrum is affected by the pH of the mobile phase. The spectra presented here are measured with an acidic mobile phase that has a pH of 3 or lower.

Application Analytes:
Sulfamethazine
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Sulfamethazine on Newcrom R1 HPLC column

February 16, 2018
Separation of Sulfamethazine on Newcrom C18 HPLC column

Sulfamethazine can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Sulfamethazine
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.

HPLC Method for Analysis of Sulfadiazine, Naphthylthiourea, Sulfamethazine, Dexamethasone, Cortisone 21-Acetate

July 11, 2017

Sulfadiazine is an antibiotic used to prevent rheumatic fever, chancroid, chlamydia and infections by Haemophilus influenzae. There are side effects to the use of the drug which include, but not limited to: nausea, headache, rash, depression.

 

Condition
Column Primesep 100, 3.2×50 mm, 5 µm, 100A
Mobile Phase Gradient MeCN – 20-75%, 4 min
Buffer Gradient H3PO4 – 0.05-0.2%, 4 min
Flow Rate 0.5 ml/min
Detection UV, 270 nm

 

Description
Class of Compounds
 Drug, Acid, Hydrophilic, Ionizable
Analyzing Compounds Sulfadiazine, Naphthylthiourea, Sulfamethazine, Dexamethasone, Cortisone 21-Acetate

 

Application Column

Primesep 100

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

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Application Analytes:
Cortisone 21-Acetate
Dexamethasone
Naphthylthiourea
Sulfadiazine
Sulfamethazine
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.