Rivastigmine

Rivastigmine structural formula

CAS Number123441-03-2
Molecular FormulaC14H22N2O2
Molecular Weight250.342
InChI KeyXSVMFMHYUFZWBK-NSHDSACASA-N
LogP2.26
Synonyms
  • Rivastigmine
  • 3-[(1S)-1-(Dimethylamino)ethyl]phenyl ethyl(methyl)carbamate
  • Carbamic acid, N-ethyl-N-methyl-, 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester
  • 123441-03-2
  • Carbamic acid, ethylmethyl-, 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester
  • 3-((1S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate
  • Carbamic acid, ethylmethyl-, 3-((1S)-1-(dimethylamino)ethyl)phenyl ester
  • ENA 713 free base
  • UNII-PKI06M3IW0
  • Nimvastid
  • Prometax
  • Rivastigmine Teva
  • SDZ ENA 713
  • Exelon Patch
  • Rivastigmine transdermal system
  • (S)-3-(1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate
  • m-((S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate

Applications:

Separation of Rivastigmine on Newcrom R1 HPLC column

February 19, 2018
Separation of Rivastigmine on Newcrom C18 HPLC column

Rivastigmine can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Rivastigmine
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.