Rasagiline

CAS Number136236-51-6
Molecular FormulaC12H13N
Molecular Weight171.24
InChI KeyRUOKEQAAGRXIBM-GFCCVEGCSA-N
LogP1.8
Synonyms
  • rasagiline
  • 136236-51-6
  • (R)-N-(2-Propynyl)-2,3-dihydroinden-1-amine
  • Azilect
  • (R)-N-2-Propynyl-1-indanamine
  • (R)-2,3-dihydro-N-2-propynyl-1H-inden-1-amine
  • 1-Indanamine, N-2-propynyl-, (R)-
  • (1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine
  • UNII-003N66TS6T
  • TV-1030
  • Azilect (TN)
  • RAS
  • CHEMBL887
  • (1R)-N-propargylindan-1-amine
  • CHEBI:63620
  • 003N66TS6T
  • (R)-Indan-1-yl-prop-2-ynyl-amine
  • 1H-Inden-1-amine, 2,3-dihydro-N-2-propynyl-, (1R)-
  • (R)-N-(prop-2-ynyl)-2,3-dihydro-1H-inden-1-amine
  • (1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine
  • Rasagiline [USAN:INN]
  • MFCD00866571
  • HSDB 7699
  • (1R)-N-prop-2-ynylindan-1-amine
  • 1H-Inden-1-amine, 2,3-dihydro-N-2-propynyl-, (1R)
  • TV 1030
  • PubChem23269
  • Rasagiline (USAN/INN)
  • SCHEMBL74699
  • cc-221
  • MLS006012042
  • N-propargyl-1-(R)aminoindan
  • GTPL6641
  • IND057
  • SCHEMBL2029054
  • DTXSID3041112
  • BDBM10989
  • HMS3264K12
  • HMS3715L12
  • HMS3886N03
  • Pharmakon1600-01502333
  • AC-723
  • ANW-49399
  • HY-14605A
  • NSC759639
  • NSC789038
  • s5795
  • ZINC19875504
  • AKOS006271452
  • AKOS015837675
  • AM84542
  • CCG-213034
  • DB01367
  • FS-3130
  • MCULE-4385913742
  • NSC-759639
  • NSC-789038
  • BR-39976
  • SMR002533187
  • (1R)-N-(prop-2-yn-1-yl)indan-1-amine

Applications:

HPLC Method for Simultaneous Analysis of Rasagiline and Pramipexole in Tablets on Primesep 100 Column

May 5, 2021

Separation type: Liquid Chromatography Mixed-mode




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High Performance Liquid Chromatography (HPLC) Method for Analysis of Rasagiline and Pramipexole





Rasagiline and Pramipexole are marvels of modern science, giving patients with Parkin’s disease a way to treat their symptoms. Interestingly, both work slightly differently. Rasagiline prevents dopamine metabolism by permanently binding to the enzyme that breaks down dopamine, monoamine oxidase-B (MOA-B), while pramipexole binds to dopamine receptors and activates them, mimicking dopamine itself.
These drugs can be detected in the low UV regime. Using a Primesep 100 reverse-phase column and a mobile phase consisting of water and acetonitrile (MeCN) with a sulfuric acid (H2SO4) buffer, Rasagiline and Pramipexole can be separated, measured, and analyzed. This analysis method can be UV detected at 264 nm.




Condition
Column Primesep 100, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 40/60%
Buffer H2SO4 – 0.4%
Flow Rate 1.0 ml/min
Detection UV, 264 nm

 

Description
Class of Compounds
 Drug
Analyzing Compounds Rasagiline,  Pramipexole

 

Application Column

Primesep 100

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Pramipexole dihydrochloride monohydrate
Rasagiline
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.