| CAS Number | 15686-83-6 |
|---|---|
| Molecular Formula | C11H14N2S |
| Molecular Weight | 206.310 |
| InChI Key | YSAUAVHXTIETRK-AATRIKPKSA-N |
| LogP | 2.11 |
| Synonyms |
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Applications:
HPLC method for Separation Pamoic Acid, Ivermectin, Pyrantel on Primesep 100 Column
February 2, 2024
High Performance Liquid Chromatography (HPLC) Method for Analysis of Pamoic acid, Ivermectin B1a, Pyrantel on Primesep 100 by SIELC Technologies
Separation type: Liquid Chromatography Mixed-mode SIELC Technologies
High Performance Liquid Chromatography (HPLC) Method for Analysis of Pamoic acid, Ivermectin B1a, Pyrantel
Pamoic Acid:
- Pamoic acid is a compound used in pharmaceuticals, particularly as a salt form.
- Its salt, such as pamoate salts, is often used to improve the solubility and stability of certain drugs.
- Pamoic acid is commonly used in the formulation of drugs to enhance their pharmacokinetic properties.
Ivermectin:
- Ivermectin is an antiparasitic medication that belongs to the class of drugs called avermectins.
- It is widely used to treat parasitic infections, including certain types of roundworm infections and scabies.
- Ivermectin works by interfering with the nervous system of parasites, leading to their paralysis and eventual death.
Pyrantel:
- Pyrantel is an anthelmintic or deworming medication.
- It is commonly used to treat infections caused by roundworms and hookworms.
- Pyrantel works by causing neuromuscular blockade in the parasites, leading to their expulsion from the digestive tract.
Pamoic Acid, Ivermectin, Pyrantel be retained, separated and analyzed using a Primesep 100 mixed-mode stationary phase column. The analysis employs an isocratic method with a simple mobile phase comprising water, acetonitrile (MeCN), and sulfuric acid as a buffer. This method allows for detection using UV 245 and 315 nm
| Column | Primesep 100, 4.6 x 150 mm, 5 µm, 100 A |
| Mobile Phase | MeCN – 60% |
| Buffer | H2SO4 -0.2% |
| Flow Rate | 1.0 ml/min |
| Detection | UV 245, 315 nm |
| Samples | Ivermectin – 0.25 mg/ml Pyrantel Pamoate – 0.25 mg/ml |
| Injection volume | 2 µl |
| LOD* | 1. 2.6 ppb (245 nm) 2. 18 ppb (245 nm) 3. 29 ppb (315 nm) |
| Class of Compounds | Drugs |
| Analyzing Compounds | Pamoic acid, Ivermectin B1a, Pyrantel |
Application Column
Primesep 100
Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Pamoic acid
Pyrantel
Separation of Pyrantel on Newcrom R1 HPLC column
February 16, 2018
Pyrantel can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.
Application Column
Newcrom R1
The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.
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