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SIELC Technologies has developed mixed-mode columns based on solid-core-porous-shell particles. These specially-designed silica nanoparticles simulate UHPLC conditions on standard HPLC systems, reducing the need for the more complex equipment typically required by UHPLC systems. This separation medium combines the efficiency of solid-core technology with the unique selectivity of Ion-Exchange (IE) mode, Reverse Phase (RP) mode, and HILIC mode. Currently, there are three mixed-mode Primesep columns available with solid-core 2.7 µm particles: Primesep 100, Primesep S, and Primesep SB.

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