Methyl 2-chloroacrylate

Methyl 2-chloroacrylate structural formula

CAS Number80-63-7
Molecular FormulaC4H5ClO2
Molecular Weight120.530
InChI KeyAWJZTPWDQYFQPQ-UHFFFAOYSA-N
LogP1.16
Synonyms
  • Methyl 2-chloroacrylate
  • Methyl 2-chloroprop-2-enoate
  • 2-Propenoic acid, 2-chloro-, methyl ester
  • 80-63-7
  • BRN 1421536
  • 2-Chloroacrylic acid, methyl ester
  • EINECS 201-298-7
  • Methyl alpha-chloroacrylate
  • Methyl 2-chloro-2-propenoate
  • Methyl-alpha-chloroacrylate
  • Methyl-2-chloroacrylate
  • NSC 32608
  • Propenoic acid, 2-chloro-, methyl ester
  • Methylester kyseliny 2-chlorakrylove

Applications:

Separation of Methyl 2-chloroacrylate on Newcrom R1 HPLC column

February 16, 2018
Separation of Methyl 2-chloroacrylate on Newcrom C18 HPLC column

Methyl 2-chloroacrylate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Methyl 2-chloroacrylate
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.