Methotrexate disodium salt

Methotrexate disodium salt structural formula

CAS Number7413-34-5
Molecular FormulaC20H20N8Na2O5
Molecular Weight498.411
InChI KeyDASQOOZCTWOQPA-GXKRWWSZSA-L
LogP-1.31
Synonyms
  • Methotrexate disodium salt
  • Disodium (2S)-2-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzamido)pentanedioate
  • L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, sodium salt (1:2)
  • 7413-34-5
  • L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, sodium salt (1:2)
  • Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, disodium salt, L-(+)-
  • L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, disodium salt
  • Amethopterin sodium
  • Methotrexate Lederle
  • Metoart
  • Metotrexato Lederle
  • Sodium methotrexate
  • disodium N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate
  • N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate de disodium
  • Dinatrium-N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamat
  • N-[4-[[(2,4-diamino-6-pteridinil)metil]metilamino]benzoil]-L-glutamato de disodio
  • 4-Amino-N(sup 10)-methylpteroylglutamic acid disodium salt
  • Disodium methotrexate
  • EINECS 231-022-0
  • MTX disodium
  • Methotrexat dinatrium
  • Methotrexate preservative free
  • Methotrexate sodium preservative free
  • Mexate-AQ preserved
  • UNII-3IG1E710ZN

Applications:

Separation of Methotrexate disodium salt on Newcrom R1 HPLC column

February 16, 2018
Separation of Methotrexate disodium salt on Newcrom C18 HPLC column

Methotrexate disodium salt can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Methotrexate disodium salt
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.